Literature DB >> 11682224

A new HPLC method to determine Donepezil hydrochloride in tablets.

Horacio Pappa1, Romina Farrú, Paula Otaño Vilanova, Marcelo Palacios, María Teresa Pizzorno.   

Abstract

A HPLC stability-indicating assay for Donepezil hydrochloride in tablets was developed and validated. Donepezil hydrochloride is a reversible inhibitor of acetylcholinesterase, indicated for the treatment of mild to moderate dementia of the Alzheimer's type. The HPLC method was performed with a reversed phase C18 column, detection at 268 nm and a mixture of methanol, phosphate buffer 0.02 M and triethylamine (50:50:0.5) as mobile phase. Typical retention time for Donepezil was 9 min. The method was statistically validated for linearity, accuracy, precision and selectivity following ICH recommendations. Due to its simplicity and accuracy, the method can be used for routine quality control analysis.

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Year:  2002        PMID： 11682224     DOI： 10.1016/s0731-7085(01)00499-x

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  5 in total

1.  Characterization of oral disintegrating film containing donepezil for Alzheimer disease.

Authors:  Kai Bin Liew; Yvonne Tze Fung Tan; Kok Khiang Peh
Journal:  AAPS PharmSciTech       Date:  2011-12-14       Impact factor: 3.246

2.  Donepezil loaded PLGA-b-PEG nanoparticles: their ability to induce destabilization of amyloid fibrils and to cross blood brain barrier in vitro.

Authors:  Ipek Baysal; Gulberk Ucar; Merve Gultekinoglu; Kezban Ulubayram; Samiye Yabanoglu-Ciftci
Journal:  J Neural Transm (Vienna)       Date:  2016-02-24       Impact factor: 3.575

3.  Development of Dapagliflozin Solid Lipid Nanoparticles as a Novel Carrier for Oral Delivery: Statistical Design, Optimization, In-Vitro and In-Vivo Characterization, and Evaluation.

Authors:  Aziz Unnisa; Ananda K Chettupalli; Turki Al Hagbani; Mohammad Khalid; Suresh B Jandrajupalli; Swarnalatha Chandolu; Talib Hussain
Journal:  Pharmaceuticals (Basel)       Date:  2022-05-02

4.  Development and Characterization of Sustained-Released Donepezil Hydrochloride Solid Dispersions Using Hot Melt Extrusion Technology.

Authors:  Abdullah Alshetaili; Bjad K Almutairy; Sultan M Alshehri; Michael A Repka
Journal:  Pharmaceutics       Date:  2021-02-04       Impact factor: 6.321

5.  Preparation, Characterization, and In Vivo Pharmacokinetic Evaluation of Polyvinyl Alcohol and Polyvinyl Pyrrolidone Blended Hydrogels for Transdermal Delivery of Donepezil HCl.

Authors:  Santosh Bashyal; Chang Yell Shin; Sang Min Hyun; Sun Woo Jang; Sangkil Lee
Journal:  Pharmaceutics       Date:  2020-03-16       Impact factor: 6.321
  5 in total

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