S G Gong1, R L Eulenberg. 1. Department of Orthodontics and Pediatric Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109-1078, USA. sggong@umich.edu
Abstract
OBJECTIVE: The development of the secondary palate of Twirler (Tw) mice was characterized, and a quantitative coronal plane evaluation of the width and length of the craniofacial regions of homozygous mutant embryos was conducted. RESULTS AND CONCLUSIONS: The secondary palatal shelves were retarded in growth and the timing of elevation from a vertical to horizontal position. The homozygous Tw embryos, when compared with their wild-type littermates, also had a significantly wider midface. It is not surprising, therefore, that the short palatal shelves in a wide midface resulted in cleftings of the secondary palate observed in all homozygous Tw mice. These findings are consistent with similar studies in humans and other murine models.
OBJECTIVE: The development of the secondary palate of Twirler (Tw) mice was characterized, and a quantitative coronal plane evaluation of the width and length of the craniofacial regions of homozygous mutant embryos was conducted. RESULTS AND CONCLUSIONS: The secondary palatal shelves were retarded in growth and the timing of elevation from a vertical to horizontal position. The homozygous Tw embryos, when compared with their wild-type littermates, also had a significantly wider midface. It is not surprising, therefore, that the short palatal shelves in a wide midface resulted in cleftings of the secondary palate observed in all homozygous Twmice. These findings are consistent with similar studies in humans and other murine models.
Authors: Magda A Meester-Smoor; Marcel Vermeij; Marjolein J L van Helmond; Anco C Molijn; Karel H M van Wely; Arnold C P Hekman; Christl Vermey-Keers; Peter H J Riegman; Ellen C Zwarthoff Journal: Mol Cell Biol Date: 2005-05 Impact factor: 4.272
Authors: Huimin Yu; Philip M Smallwood; Yanshu Wang; Roman Vidaltamayo; Randall Reed; Jeremy Nathans Journal: Development Date: 2010-11 Impact factor: 6.868