| Literature DB >> 11680572 |
A M Lehnert1, P L Mottram, W Han, S N Walters, A T Patel, W J Hawthorne, P J Cowan, A J d'Apice, P J O'Connell.
Abstract
Previously, we demonstrated that combination CTLA4-Fc and anti-CD40L mAb treatment results in tolerance to concordant, cellular islet xenografts. The aim of this study was to determine its effectiveness in a model of fetal pig pancreas (FPP) xenotransplantation. Survival of FPP fragment grafts were compared to the survival of rat islet or cardiac xenografts following short term CTLA4-Fc and anti-CD40L mAb treatment. Rat islet and FPP fragment grafts survived long-term. However, rat cardiac grafts were rejected by 52-91 days. Both rat islet and FPP grafts showed similar histology with intact islet structures and adjacent 'nests' of lymphocytes. Concordant vascularised rat hearts showed extensive polymorphonuclear infiltrate, concentric vasculitis and a perivascular infiltrate predominantly of CD8+ T cells. This suggests that this therapy is effective for prolonging islet xenografts and demonstrates that the cellular mechanism of rejection for vascularised and non-vascularised xenografts are different.Entities:
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Year: 2001 PMID： 11680572 DOI： 10.1016/s0966-3274(01)00040-5
Source DB: PubMed Journal: Transpl Immunol ISSN： 0966-3274 Impact factor: 1.708