Literature DB >> 11678650

Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis.

J Ito1, F R Chang, H K Wang, Y K Park, M Ikegaki, N Kilgore, K H Lee.   

Abstract

A new triterpenoid named melliferone (1), three known triterpenoids, moronic acid (2), anwuweizonic acid (3), and betulonic acid (4), and four known aromatic compounds (5-8) were isolated from Brazilian propolis and tested for anti-HIV activity in H9 lymphocytes. Moronic acid (2) showed significant anti-HIV activity (EC(50) <0.1 microg/mL, TI >186) and was modified to develop more potent anti-AIDS agents.

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Year:  2001        PMID： 11678650     DOI： 10.1021/np010211x

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  38 in total

1.  In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori.

Authors:  Sotirios Paraschos; Prokopios Magiatis; Sofia Mitakou; Kalliopi Petraki; Antonios Kalliaropoulos; Petros Maragkoudakis; Andreas Mentis; Dionyssios Sgouras; Alexios-Leandros Skaltsounis
Journal:  Antimicrob Agents Chemother       Date:  2006-11-20       Impact factor: 5.191

2.  Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents.

Authors:  Donglei Yu; Yojiro Sakurai; Chin-Ho Chen; Fang-Rong Chang; Li Huang; Yoshiki Kashiwada; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2006-09-07       Impact factor: 7.446

Review 3.  Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.

Authors:  Kuo-Hsiung Lee
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050

4.  Bioactive constituents from the roots of Panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds.

Authors:  Hsiu-Hui Chan; Tsong-Long Hwang; Mopur Vijaya Bhaskar Reddy; Ding-Tzai Li; Keduo Qian; Kenneth F Bastow; Kuo-Hsiung Lee; Tian-Shung Wu
Journal:  J Nat Prod       Date:  2011-03-18       Impact factor: 4.050

5.  Comparison of the effects of pachymic acid, moronic acid and hydrocortisone on the polysome loading of RNAs in lipopolysaccharide-treated THP-1 macrophages.

Authors:  Tomohito Kakegawa; Lucia Satiko Yoshida; Mariko Takada; Mari Noguchi; Ken Yasukawa; Hiromi Takano-Ohmuro
Journal:  J Nat Med       Date:  2018-11-09       Impact factor: 2.343

6.  Molecular characterization of propolis-induced cell death in Saccharomyces cerevisiae.

Authors:  Patrícia Alves de Castro; Marcela Savoldi; Diego Bonatto; Mário Henrique Barros; Maria Helena S Goldman; Andresa A Berretta; Gustavo Henrique Goldman
Journal:  Eukaryot Cell       Date:  2010-12-30

Review 7.  Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents.

Authors:  Reen-Yen Kuo; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Nat Prod Rep       Date:  2009-08-13       Impact factor: 13.423

8.  Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors.

Authors:  Keduo Qian; Reen-Yun Kuo; Chin-Ho Chen; Li Huang; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2010-04-22       Impact factor: 7.446

9.  Transcriptional profiling of Saccharomyces cerevisiae exposed to propolis.

Authors:  Patrícia Alves de Castro; Marcela Savoldi; Diego Bonatto; Iran Malavazi; Maria Helena S Goldman; Andresa A Berretta; Gustavo Henrique Goldman
Journal:  BMC Complement Altern Med       Date:  2012-10-24       Impact factor: 3.659

10.  Recent progress of propolis for its biological and chemical compositions and its botanical origin.

Authors:  Viviane Cristina Toreti; Helia Harumi Sato; Glaucia Maria Pastore; Yong Kun Park
Journal:  Evid Based Complement Alternat Med       Date:  2013-04-30       Impact factor: 2.629
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