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Literature DB >> 116785

Suppressive effect of IgA soluble immune complexes on neutrophil chemotaxis.

S Ito, H Mikawa, K Shinomiya, T Yoshida.

Abstract

The effect of IgA and IgG soluble immune complexes (SIC) on neutrophil chemotaxis was investigated. Six types of SIC were prepared from kappa-type IgA and IgG myeloma proteins: IgA-anti-kappa chain antibody SIC in IgA excess, IgA-anti-kappa chain antibody in SIC in anti-kappa chain antibody excess, IgA-anti-alpha chain antibody SIC in IgA excess, IgG-anti-kappa chain antibody SIC in IgG excess, IgG-anti-kappa chain antibody SIC in anti-kappa chain antibody excess, and IgG-anti-gamma chain antibody SIC in IgG excess. Three types of IgA SIC had a marked suppressive effect on neutrophil chemotaxis, while IgG SIC, free IgA, free anti-kappa chain antibody, and free anti-gamma chain antibody showed no inhibitory activity. This suppressive effect on neutrophil chemotaxis caused specifically by polymerized IgA was a cell-directed one and was expressed in a concentration dependent manner.

Entities: Disease

Mesh：

Substances：

Year: 1979 PMID： 116785 PMCID： PMC1537781

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

11 in total

1. Immunoglobulins cytophilic for human lymphocytes, monocytes, and neutrophils.

Authors: D A Lawrence; W O Weigle; H L Spiegelberg
Journal: J Clin Invest Date: 1975-02 Impact factor: 14.808

2. A new supporting medium for preparative electrophoresis.

Authors: H J MULLER-EBERHARD
Journal: Scand J Clin Lab Invest Date: 1960 Impact factor: 1.713

3. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

4. Suppression of human PMN bactericidal activity by human IgA paraproteins.

Authors: D E Van Epps; K Reed; R C Williams
Journal: Cell Immunol Date: 1978-03-15 Impact factor: 4.868

5. Cytophilic properties of IgA to human neutrophils.

Authors: H L Spiegelberg; D A Lawrence; P Henson
Journal: Adv Exp Med Biol Date: 1974 Impact factor: 2.622

6. The release of granule enzymes from human neutrophils stimulated by aggregated immunoglobulins of different classes and subclasses.

Authors: P M Henson; H B Johnson; H L Spiegelberg
Journal: J Immunol Date: 1972-12 Impact factor: 5.422

7. Defective granulocyte chemotaxis in the Chediak-Higashi syndrome.

Authors: R A Clark; H R Kimball
Journal: J Clin Invest Date: 1971-12 Impact factor: 14.808

8. Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for polymorphonuclear leukocytes.

Authors: R Snyderman; H Gewurz; S E Mergenhagen
Journal: J Exp Med Date: 1968-08-01 Impact factor: 14.307

9. Serum opsonin, bacteria, and polymorphonuclear leukocyte interactions in subacute bacterial endocarditis. Anti-gamma-globulin factors and their interaction with specific opsonins.

Authors: R P Messner; T Laxidal; P G Quie; R C Williams
Journal: J Clin Invest Date: 1968-05 Impact factor: 14.808

10. Chemotaxis of polymorphonuclear leukocytes from patients with rheumatoid arthritis.

Authors: A G Mowat; J Baum
Journal: J Clin Invest Date: 1971-12 Impact factor: 14.808

6 in total

1. The specificity of the human neutrophil IgA receptor (Fc alpha R) determined by measurement of chemiluminescence induced by serum or secretory IgA1 or IgA2.

Authors: W W Stewart; M A Kerr
Journal: Immunology Date: 1990-11 Impact factor: 7.397

2. Selective immunoglobulin M deficiency associated with disseminated molluscum contagiosum.

Authors: M Mayumi; K Yamaoka; T Tsutsui; H Mizue; A Doi; M Matsuyama; S Ito; K Shinomiya; H Mikawa
Journal: Eur J Pediatr Date: 1986-04 Impact factor: 3.183

3. Inhibition of formylmethionyl-leucyl-phenylalanine-stimulated neutrophil chemiluminescence by human immunoglobulin A paraproteins.

Authors: D E Van Epps; S L Brown
Journal: Infect Immun Date: 1981-12 Impact factor: 3.441