Literature DB >> 11677135

Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis.

K G Liu1, M H Lambert, L M Leesnitzer, W Oliver, R J Ott, K D Plunket, L W Stuart, P J Brown, T M Willson, D D Sternbach.   

Abstract

We have developed a general solid-phase synthesis for identification of PPAR ligands. Synthesis of a 480-member library led to the identification of a potent PPAR gamma/delta dual agonist 23. Compound 23 showed good plasma exposure in rats and demonstrated antihyperglycemic and antihyperlipidemic efficacy in diabetic fatty Zucker rats.

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Year:  2001        PMID： 11677135     DOI： 10.1016/s0960-894x(01)00596-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Peroxisome proliferator-activated receptors target family landscape: a chemometrical approach to ligand selectivity based on protein binding site analysis.

Authors:  Bernard Pirard
Journal:  J Comput Aided Mol Des       Date:  2003-11       Impact factor: 3.686

2.  Para amino benzoic acid-derived self-assembled biocompatible nanoparticles for efficient delivery of siRNA.

Authors:  Teegala Lakshminarayan Reddy; P Sivarama Krishnarao; Garikapati Koteswara Rao; Eswar Bhimireddy; P Venkateswarlu; Debendra K Mohapatra; J S Yadav; Utpal Bhadra; Manika Pal Bhadra
Journal:  Int J Nanomedicine       Date:  2015-10-12
  2 in total

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