Literature DB >> 11677134

Design and synthesis of potent and selective inhibitors of integrin VLA-4.

S Wattanasin1, B Weidmann, D Roche, S Myers, A Xing, Q Guo, M Sabio, P von Matt, R Hugo, S Maida, P Lake, M Weetall.   

Abstract

The synthesis and identification of a novel series of inhibitors of integrin VLA-4 are described. Their in vitro activity and selectivity against closely related integrins are also presented.

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Year:  2001        PMID: 11677134     DOI: 10.1016/s0960-894x(01)00586-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  An alpha4beta1 integrin antagonist decreases airway inflammation in ovalbumin-exposed mice.

Authors:  Nicholas J Kenyon; Ruiwu Liu; Erin M O'Roark; Wenzhe Huang; Li Peng; Kit S Lam
Journal:  Eur J Pharmacol       Date:  2008-12-13       Impact factor: 4.432

  1 in total

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