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Literature DB >> 11677047

Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts.

J P Spencer¹, H Schroeter, A J Crossthwaithe, G Kuhnle, R J Williams, C Rice-Evans.

Abstract

The purpose of this study was to examine the comparative mechanisms by which the dietary form of the flavonoid epicatechin and its predominant in vivo metabolite, epicatechin glucuronide, influence oxidative stress-induced cell death in fibroblasts and neurons. The results demonstrate the contrasting influences of in vivo glucuronidation and methylation on the bioactivity of epicatechin.

Entities: Chemical

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Year: 2001 PMID： 11677047 DOI： 10.1016/s0891-5849(01)00704-3

Source DB: PubMed Journal: Free Radic Biol Med ISSN： 0891-5849 Impact factor: 7.376

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Cited

20 in total

1. Enzymatic synthesis of substituted epicatechins for bioactivity studies in neurological disorders.

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Journal: Biochem J Date: 2003-05-15 Impact factor: 3.857

Review 5. Are Polyphenols Strong Dietary Agents Against Neurotoxicity and Neurodegeneration?

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Journal: Neurotox Res Date: 2016-01-08 Impact factor: 3.911

6. Comparison of enzymically glucuronidated flavonoids with flavonoid aglycones in an in vitro cellular model of oxidative stress protection.

Authors: David E Stevenson; Janine M Cooney; Dwayne J Jensen; Reginald Wibisono; Aselle Adaim; Margot A Skinner; Jingli Zhang
Journal: In Vitro Cell Dev Biol Anim Date: 2008-01-25 Impact factor: 2.416

Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts.

1. Enzymatic synthesis of substituted epicatechins for bioactivity studies in neurological disorders.

2. Difference in chilling-induced flavonoid profiles, antioxidant activity and chilling tolerance between soybean near-isogenic lines for the pubescence color gene.

3. Nutritional flavonoids impact on nuclear and extranuclear estrogen receptor activities.

4. Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites.

Review 5. Are Polyphenols Strong Dietary Agents Against Neurotoxicity and Neurodegeneration?

6. Comparison of enzymically glucuronidated flavonoids with flavonoid aglycones in an in vitro cellular model of oxidative stress protection.

7. Glycosylation of resveratrol protects it from enzymic oxidation.

8. Flavonoids and brain health: multiple effects underpinned by common mechanisms.

9. The interactions of flavonoids within neuronal signalling pathways.

10. The neuroprotective potential of flavonoids: a multiplicity of effects.