Literature DB >> 1167671

An isolated guinea pig heart preparation with in vivo like features.

R Bünger, F J Haddy, A Querengässer, E Gerlach.   

Abstract

Hemodynamic and metabolic characteristics of an isolated guinea pig heart preparation perfused with a pyruvate fortified Krebs-Ringer-bicarbonate solution are described. The preparation is stable for more than 90 min with respect to coronary flow, heart rate, left ventricular pressure, dP/dt, oxygen consumption, and myocardial high energy phosphate levels. The changes in coronary flow induced by alterations of perfusion pressure, ischemia, and hypoxia resemble those seen under in vivo conditions. The preparation also exhibits concentration dependent and reproducible changes in coronary resistance upon administration of adenosine and papaverine. The in vivo like features of this preparation can be mainly attributed to the use of pyruvate as additional and preferentially utilized substrate. The preparation appears to be suitable for quantitative studies of myocardial metabolism and heart function as well as for investigations of the coronary system.

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Year:  1975        PMID： 1167671     DOI： 10.1007/bf00587028

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  14 in total

1.  [ON THE BEHAVIOR OF NUCLEOTIDES AND THEIR DEPHOSPHORYLATION DEGRADATION PRODUCTS IN THE KIDNEY IN ISCHEMIA AND SHORT-TERM POST-ISCHEMIC RE-ESTABLISHMENT OF BLOOD CIRCULATION].

Authors:  E GERLACH; B DEUTICKE; R H DREISBACH; C W ROSARIUS
Journal:  Pflugers Arch Gesamte Physiol Menschen Tiere       Date:  1963-11-11

2.  The oxygen uptake of the perfused rat heart.

Authors:  R B FISHER; J R WILLIAMSON
Journal:  J Physiol       Date:  1961-09       Impact factor: 5.182

3.  Reactive hyperemia characteristics of the myocardium.

Authors:  J D COFFMAN; D E GREGG
Journal:  Am J Physiol       Date:  1960-12

4.  [Regulation of pyruvate dehydrogenase activity and dynamics of the isolated perfused guinea pig heart in thiamine deficiency].

Authors:  B Gessner; E R Müller-Ruchholtz; H Reinauer
Journal:  Pflugers Arch       Date:  1972       Impact factor: 3.657

5.  Myocardial reactive hyperemia: comparative effects of adenosine, ATP, ADP, and AMP.

Authors:  T W Moir; T D Downs
Journal:  Am J Physiol       Date:  1972-06

6.  Metabolic adjustments to acute heart work: observations in the isolated perfused rat heart.

Authors:  L H Opie; P Owen; K R Mansford
Journal:  Cardiovasc Res       Date:  1971-07       Impact factor: 10.787

7.  The importance of the perfusion pressure in the coronary arteries for the contractility and the oxygen consumption of the heart.

Authors:  G Arnold; F Kosche; E Miessner; A Neitzert; W Lochner
Journal:  Pflugers Arch Gesamte Physiol Menschen Tiere       Date:  1968

8.  Metabolic, ultrastructural, and mechanical changes in the isolated rat heart perfused with aerobic medium in the absence or presence of glucose.

Authors:  N S Dhalla; R F Matoushek; C N Sun; R E Olson
Journal:  Can J Physiol Pharmacol       Date:  1973-08       Impact factor: 2.273

9.  Pyruvate metabolism in the perfused rat heart.

Authors:  J R Evans; L H Opie; A E Renold
Journal:  Am J Physiol       Date:  1963-11

10.  Local effects of O2 and CO2 on limb, renal, and coronary vascular resistances.

Authors:  R M Daugherty; J B Scott; J M Dabney; F J Haddy
Journal:  Am J Physiol       Date:  1967-11
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  24 in total

1.  The effect of isolation on myocardial properties.

Authors:  H Reichel
Journal:  Basic Res Cardiol       Date:  1976 Jan-Feb       Impact factor: 17.165

2.  Comparison between left and right heart function in the isolated biventricular working rat heart.

Authors:  Gerhard Müller-Strahl; Jan Hemker; Heinz-Gerd Zimmer
Journal:  Exp Clin Cardiol       Date:  2002

3.  Studies on potassium induced coronary dilation in the isolated guinea pig heart.

Authors:  R Bünger; R J Haddy; A Querengässer; E Gerlach
Journal:  Pflugers Arch       Date:  1976-05-06       Impact factor: 3.657

4.  Induced functional modulations of isolated large mammalian hearts.

Authors:  Brian T Howard; Paul A Iaizzo
Journal:  Pflugers Arch       Date:  2019-05-23       Impact factor: 3.657

5.  Effects of pyruvate on post-ischemic myocardial recovery at various workloads.

Authors:  M van Bilsen; G J van der Vusse; L H Snoeckx; T Arts; W A Coumans; P H Willemsen; R S Reneman
Journal:  Pflugers Arch       Date:  1988-12       Impact factor: 3.657

6.  Functional and metabolic features of an isolated perfused guinea pig heart performing pressure-volume work.

Authors:  R Bünger; O Sommer; G Walter; H Stiegler; E Gerlach
Journal:  Pflugers Arch       Date:  1979-07       Impact factor: 3.657

7.  Modulation of mitochondrial bioenergetics in the isolated Guinea pig beating heart by potassium and lidocaine cardioplegia: implications for cardioprotection.

Authors:  Mohammed Aldakkak; David F Stowe; Edward J Lesnefsky; James S Heisner; Qun Chen; Amadou K S Camara
Journal:  J Cardiovasc Pharmacol       Date:  2009-10       Impact factor: 3.105

8.  Energy utilization and pyruvate as determinants of pyruvate dehydrogenase in norepinephrine-stimulated heart.

Authors:  R Bünger; B Permanetter; S Yaffe
Journal:  Pflugers Arch       Date:  1983-05       Impact factor: 3.657

9.  Effects of temperature on anion distribution in perfused rat, guinea-pig and hamster ventricle.

Authors:  D D Macchia; P W Bankston
Journal:  Experientia       Date:  1983-11-15

10.  Myocardial adenosine stimulates release of cyclic adenosine monophosphate from capillary endothelial cells in guinea pig heart.

Authors:  K Kroll; J Schrader
Journal:  Pflugers Arch       Date:  1993-05       Impact factor: 3.657
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