BACKGROUND: This study was undertaken to determine the effects of month-long whole grain oat and wheat cereal supplementation on endothelial function following a fatty meal as measured by brachial artery reactivity studies. METHODS: Fifty healthy adult subjects underwent brachial artery reactivity studies before and after a high-fat meal along with alpha-tocopherol (vitamin E), oats, or a comparable bowl of wheat cereal and were again tested after the high-fat meal following month-long supplementation with oat or wheat cereal in a random crossover with interim washout. RESULTS: In the acute phase, the fatty meal attenuated the hyperemic brachial artery flow response when administered concurrently with wheat cereal (-13.4%; P = 0.02), whereas hyperemic flow was maintained by concurrent administration of either oatmeal or alpha-tocopherol. Following month-long supplementation, postprandial peak flow (wheat +3.88 +/- 5.62%; oat -10.78 +/- 7.15%), and peak diameter (wheat -1.40 +/- 0.96%; oat -0.86 +/- 0.88%) did not differ from preprandial values. Oat and wheat treatments did not differ when directly compared. CONCLUSIONS: Month-long, daily supplementation with either whole-grain oat or wheat cereal may prevent postprandial impairment of vascular reactivity in response to a high-fat meal. Copyright 2001 American Health Foundation and Academic Press.
BACKGROUND: This study was undertaken to determine the effects of month-long whole grain oat and wheat cereal supplementation on endothelial function following a fatty meal as measured by brachial artery reactivity studies. METHODS: Fifty healthy adult subjects underwent brachial artery reactivity studies before and after a high-fat meal along with alpha-tocopherol (vitamin E), oats, or a comparable bowl of wheat cereal and were again tested after the high-fat meal following month-long supplementation with oat or wheat cereal in a random crossover with interim washout. RESULTS: In the acute phase, the fatty meal attenuated the hyperemic brachial artery flow response when administered concurrently with wheat cereal (-13.4%; P = 0.02), whereas hyperemic flow was maintained by concurrent administration of either oatmeal or alpha-tocopherol. Following month-long supplementation, postprandial peak flow (wheat +3.88 +/- 5.62%; oat -10.78 +/- 7.15%), and peak diameter (wheat -1.40 +/- 0.96%; oat -0.86 +/- 0.88%) did not differ from preprandial values. Oat and wheat treatments did not differ when directly compared. CONCLUSIONS: Month-long, daily supplementation with either whole-grain oat or wheat cereal may prevent postprandial impairment of vascular reactivity in response to a high-fat meal. Copyright 2001 American Health Foundation and Academic Press.
Authors: Hongyu Wu; Alan J Flint; Qibin Qi; Rob M van Dam; Laura A Sampson; Eric B Rimm; Michelle D Holmes; Walter C Willett; Frank B Hu; Qi Sun Journal: JAMA Intern Med Date: 2015-03 Impact factor: 21.873
Authors: Alan J Flint; Frank B Hu; Robert J Glynn; Majken K Jensen; Mary Franz; Laura Sampson; Eric B Rimm Journal: Am J Clin Nutr Date: 2009-07-01 Impact factor: 7.045
Authors: Haidong Kan; June Stevens; Gerardo Heiss; Ronald Klein; Kathryn M Rose; Stephanie J London Journal: Am J Clin Nutr Date: 2007-12 Impact factor: 7.045
Authors: Sarah Am Kelly; Louise Hartley; Emma Loveman; Jill L Colquitt; Helen M Jones; Lena Al-Khudairy; Christine Clar; Roberta Germanò; Hannah R Lunn; Gary Frost; Karen Rees Journal: Cochrane Database Syst Rev Date: 2017-08-24