Literature DB >> 1167559

Host-derived antibody-forming cells in lethally irradiated mice.

L M Pilarski, A J Cunningham.   

Abstract

The technique of adoptively transferring an immune response by injecting donor cells into irradiated recipient mice is based on the assumption that the host is rendered immunologically inert by irradiation. We present evidence that these mice are not inert; in the presence of donor cells of various types they mount a substantial immune response against both heterologous erythrocytes and dinitrophenylated bovine serum albumin. This restoration of the host requires donor cells for its expression and can account for up to 100% of the total response. The problems associated with this finding are discussed.

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Year:  1975        PMID： 1167559

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  7 in total

1.  Plasmodium chabaudi in mice. Adoptive transfer of immunity with enriched populations of spleen T and B lymphocytes.

Authors:  V McDonald; R S Phillips
Journal:  Immunology       Date:  1978-05       Impact factor: 7.397

2.  T and B cells in the transfer of immunity against Trichinella spiralis in mice.

Authors:  D Wakelin; M M Wilson
Journal:  Immunology       Date:  1979-05       Impact factor: 7.397

3.  Heteroantisera prepared against B lymphocytes at different stages of differentiation. II. Functional analysis of cytotoxicity to different B-cell populations.

Authors:  R M Gorczynski
Journal:  Immunology       Date:  1977-05       Impact factor: 7.397

4.  Clones producing antibodies of more than one class.

Authors:  H Kolb; M J Bosma
Journal:  Immunology       Date:  1977-10       Impact factor: 7.397

5.  Antigen-initiated B-lymphocyte differentiation. VIII. Sedimentation velocity and buoyant density characterization of virgin antibody-forming cell progenitors in the adoptive immune response of unprimed CBA mice to 4-hydroxy-3-iodo-5-nitrophenylacetic acid-polymerized bacterial flagellin antigen.

Authors:  J M Fidler; M C Howard; K Shortman
Journal:  J Exp Med       Date:  1976-05-01       Impact factor: 14.307

6.  The fate of fetal and adult B-cell progenitors grafted into immunodeficient CBA/N mice.

Authors:  C J Paige; P W Kincade; M A Moore; G Lee
Journal:  J Exp Med       Date:  1979-09-19       Impact factor: 14.307

7.  Alteration of clonal profile. III. T15 ontogenetic advantages are not sufficient for establishing idiotypic dominance in adoptive transfer.

Authors:  Z S Quan; J Quintáns
Journal:  J Exp Med       Date:  1981-11-01       Impact factor: 14.307
  7 in total

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