Linkage of the loci for glucose-6-phosphate dehydrogenase and for inosinic acid pyrophosphorylase to the X chromosome of the field-vole Microtus agrestis.

It has been proposed that there are strong selective pressures which have acted during the evolution of mammals to conserve the linkage of genes on the X chromosome. If so, loci that are known to be X-linked in one mammalian species should be X-linked in others. The loci for glucose-6-phosphate dehydrogenase (E.C. 1.1.1.49) and for inosinic acid pyrophosphorylase (E.C. 2.4.2.8) are known to be X-linked in a variety of mammals. The linkage of these loci to the X chromosome of the field-vole, Microtus agrestis, is indicated by the pattern of segregation of these loci in hybrid cells derived by fusion of mouse cells with vole lymphocytes.