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Literature DB >> 1167549

The amino acid sequence of a hypothalamic peptide, neurotensin.

Abstract

The amino acid sequence of neurotensin, a hypotensive peptide isolated from acid-acetone extracts of bovine hypothalami, has been established as less than Glu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-Oh. (The nomenclature and symbols follow the suggestions of the IUPAC-IUB Commission on Biochemical Nomenclature (1972) J. Biol. Chem. 247, 977). This was accomplished by sequence analyses performed on the intact peptide as well as its isolated tryptic, chymotryptic, and papain-generated fragments. The results of enzymic hydrolyses were consistent with the specificities of the enzymes used and indicated that all of the amino acids are unsubstituted and in the L configuration. The absence of non-amino acid constituents was further supported by analyses of electrophoretic mobility-molecular weight relationships of neurotensin and its fragments.

Entities: Chemical Disease Gene Species

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Year: 1975 PMID： 1167549

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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Cited

43 in total

1. Peptide nucleic acids targeted to the neurotensin receptor and administered i.p. cross the blood-brain barrier and specifically reduce gene expression.

Authors: B M Tyler; K Jansen; D J McCormick; C L Douglas; M Boules; J A Stewart; L Zhao; B Lacy; B Cusack; A Fauq; E Richelson
Journal: Proc Natl Acad Sci U S A Date: 1999-06-08 Impact factor: 11.205

2. Chemistry of natural and synthetic hypothalamic hormones.

Authors: R Geiger; J Sandow
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1977 Impact factor: 3.000

3. Neurotensin effects on evoked release of dopamine in slices from striatum, nucleus accumbens and prefrontal cortex in rat.

Authors: E Hétier; A Boireau; P Dubédat; J C Blanchard
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1988-01 Impact factor: 3.000

4. Modifications at Arg and Ile Give Neurotensin(8-13) Derivatives with High Stability and Retained NTS₁ Receptor Affinity.

Authors: Lisa Schindler; Günther Bernhardt; Max Keller
Journal: ACS Med Chem Lett Date: 2019-05-10 Impact factor: 4.345

5. Signatures of Mechanically Interlocked Topology of Lasso Peptides by Ion Mobility-Mass Spectrometry: Lessons from a Collection of Representatives.

Authors: Kevin Jeanne Dit Fouque; Hélène Lavanant; Séverine Zirah; Julian D Hegemann; Marcel Zimmermann; Mohamed A Marahiel; Sylvie Rebuffat; Carlos Afonso
Journal: J Am Soc Mass Spectrom Date: 2016-11-03 Impact factor: 3.109

The amino acid sequence of a hypothalamic peptide, neurotensin.

1. Peptide nucleic acids targeted to the neurotensin receptor and administered i.p. cross the blood-brain barrier and specifically reduce gene expression.

2. Chemistry of natural and synthetic hypothalamic hormones.

3. Neurotensin effects on evoked release of dopamine in slices from striatum, nucleus accumbens and prefrontal cortex in rat.

4. Modifications at Arg and Ile Give Neurotensin(8-13) Derivatives with High Stability and Retained NTS₁ Receptor Affinity.

5. Signatures of Mechanically Interlocked Topology of Lasso Peptides by Ion Mobility-Mass Spectrometry: Lessons from a Collection of Representatives.

6. Immunohistochemical demonstration of neurotensin and tyrosine hydroxylase in iris nerves of the rabbit eye.

Review 7. Evolution of the restorative proctocolectomy and its effects on gastrointestinal hormones.

8. Sex difference in the neurotensin-immunoreactive cell populations of the preoptic area in quail (Coturnix japonica).

9. Immunohistochemical localization of neurotensin in endocrine cells of the gut.

10. Neurotensin and its amide analogue [Gln4]-neurotensin: effects on brain monoamine turnover.