Literature DB >> 11673820

A genomewide search for quantitative-trait loci underlying asthma.

X Xu1, Z Fang, B Wang, C Chen, W Guang, Y Jin, J Yang, S Lewitzky, A Aelony, A Parker, J Meyer, S T Weiss, X Xu1.   

Abstract

A genomewide screen for quantitative-trait loci (QTLs) that underlie asthma was performed on 533 Chinese families with asthma, by the unified Haseman-Elston method. Nine asthma-related phenotypes were studied, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), airway responsiveness as indicated by methacholine (MTCH)-challenge test, serum total immunoglobulin E (TIgE), serum-specific immunoglobulin E, eosinophil count in peripheral blood, and skin-prick tests with three different allergens (cockroach, Dermatophagoides pteronyssinus, and D. farinae). Our study showed significant linkage between airway responsiveness to MTCH and D2S1780 on chromosome 2 (P<.00002) and provided suggestive evidence (P<.002) for six additional possible QTLs: D10S1435 and D22S685, for FEV1; D16S412, for FVC; D19S433, for airway responsiveness to MTCH; D1S518, for TIgE; and D4S1647, for skin reactivity to cockroach. No significant or suggestive evidence of linkage for the other four traits was found.

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Year:  2001        PMID： 11673820      PMCID： PMC1235539          DOI： 10.1086/324650

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  24 in total

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Journal:  Hum Mol Genet       Date:  1999-12       Impact factor: 6.150

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  29 in total

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Journal:  Am J Hum Genet       Date:  2002-07-15       Impact factor: 11.025

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Journal:  Hum Genet       Date:  2003-10-25       Impact factor: 4.132

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Review 6.  African Americans with asthma: genetic insights.

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7.  A large-scale genome-wide linkage analysis to map loci linked to stature in Chinese population.

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Journal:  J Clin Endocrinol Metab       Date:  2008-08-26       Impact factor: 5.958

8.  Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness.

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9.  Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy.

Authors:  Emmanuelle Bouzigon; Paola Forabosco; Gerard H Koppelman; William O C M Cookson; Marie-Hélène Dizier; David L Duffy; David M Evans; Manuel A R Ferreira; Juha Kere; Tarja Laitinen; Giovanni Malerba; Deborah A Meyers; Miriam Moffatt; Nicholas G Martin; Mandy Y Ng; Pier Franco Pignatti; Mathias Wjst; Francine Kauffmann; Florence Demenais; Cathryn M Lewis
Journal:  Eur J Hum Genet       Date:  2010-01-13       Impact factor: 4.246

10.  Identification of novel chromosomal regions associated with airway hyperresponsiveness in recombinant congenic strains of mice.

Authors:  Pierre Camateros; Rafael Marino; Anny Fortin; James G Martin; Emil Skamene; Rob Sladek; Danuta Radzioch
Journal:  Mamm Genome       Date:  2009-12-15       Impact factor: 2.957
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