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Literature DB >> 11673658

ANX7 as a bio-marker in prostate and breast cancer progression.

M Srivastava¹, L Bubendorf, L Nolan, M Glasman, X Leighton, G Miller, W Fehrle, M Raffeld, O Eidelman, O P Kallioniemi, S Srivastava, H B Pollard.

Abstract

The ANX7 gene codes for a Ca2+-activated GTPase, which has been implicated in both exocytotic secretion in cells and control of growth. In this review, we summarize information regarding increased tumor frequency in the Anx7 knockout mice, ANX7 growth suppression of human cancer cell lines, and ANX7 expression in human tumor tissue micro-arrays. The loss of ANX7 is significant in metastatic and hormone refractory prostate cancer compared to benign prostatic hyperplasia. In addition, ANX7 expression has prognostic value for predicting survival of breast cancer patients.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2001 PMID： 11673658 PMCID： PMC3851363 DOI： 10.1155/2001/239602

Source DB: PubMed Journal: Dis Markers ISSN： 0278-0240 Impact factor: 3.434

7 in total

1. Expression of annexin A7 and its clinical significance in differentiation and metastasis of gastric carcinoma.

Authors: Hu-Fang Yuan; Yong Li; Qun Zhao; Li-Qiao Fan; Bi-Bo Tan; Wei-Hua Ye
Journal: Int J Clin Exp Pathol Date: 2014-09-15

2. Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse.

Authors: Meera Srivastava; Cristina Montagna; Ximena Leighton; Mirta Glasman; Shanmugam Naga; Ofer Eidelman; Thomas Ried; Harvey B Pollard
Journal: Proc Natl Acad Sci U S A Date: 2003-11-07 Impact factor: 11.205

3. Permutation-based identification of important biomarkers for complex diseases via machine learning models.

Authors: Xinlei Mi; Baiming Zou; Fei Zou; Jianhua Hu
Journal: Nat Commun Date: 2021-05-21 Impact factor: 14.919

4. Leptin Receptor (LEPR) promotes proliferation, migration, and invasion and inhibits apoptosis in hepatocellular carcinoma by regulating ANXA7.

Authors: He Huang; Jun Zhang; Fei Ling; Yuhong Huang; Min Yang; Yao Zhang; Yuanyi Wei; Qingqing Zhang; Honghai Wang; Lin Song; Ying Wu; Jiayu Yang; Jianwu Tang
Journal: Cancer Cell Int Date: 2021-01-04 Impact factor: 5.722

ANX7 as a bio-marker in prostate and breast cancer progression.

1. Expression of annexin A7 and its clinical significance in differentiation and metastasis of gastric carcinoma.

2. Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse.

3. Permutation-based identification of important biomarkers for complex diseases via machine learning models.

4. Leptin Receptor (LEPR) promotes proliferation, migration, and invasion and inhibits apoptosis in hepatocellular carcinoma by regulating ANXA7.

Review 5. Pathobiological functions and clinical implications of annexin dysregulation in human cancers.

6. Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells.

7. Label-free quantitative proteomics and N-terminal analysis of human metastatic lung cancer cells.