Literature DB >> 1167256

Folate transport by the choroid plexus in vitro.

R Spector, A V Lorenzo.   

Abstract

Reduced folates are transported from blood into cerebrospinal fluid against a concentration gradient. In vitro, folates were transported into and released by isolated rabbit choroid plexuses. The choroid plexus uptake mechanism was specific for folates, energy dependent, and depressed by cold temperatures. In vivo, the choroid plexus may transport folates from blood to cerebrospinal fluid.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 1167256     DOI： 10.1126/science.1167256

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  14 in total

Review 1.  Vectorial ligand transport through mammalian choroid plexus.

Authors:  Reynold Spector; Conrad E Johanson
Journal:  Pharm Res       Date:  2010-05-15       Impact factor: 4.200

2.  Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter.

Authors:  Larry H Matherly; Zhanjun Hou
Journal:  Vitam Horm       Date:  2008       Impact factor: 3.421

Review 3.  Micronutrient and urate transport in choroid plexus and kidney: implications for drug therapy.

Authors:  Reynold Spector; Conrad Johanson
Journal:  Pharm Res       Date:  2006-10-18       Impact factor: 4.200

4.  Blood-brain barrier transport of reduced folic acid.

Authors:  D Wu; W M Pardridge
Journal:  Pharm Res       Date:  1999-03       Impact factor: 4.200

Review 5.  The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.

Authors:  Larry H Matherly; Mike R Wilson; Zhanjun Hou
Journal:  Drug Metab Dispos       Date:  2014-01-06       Impact factor: 3.922

Review 6.  Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues.

Authors:  Rongbao Zhao; Larry H Matherly; I David Goldman
Journal:  Expert Rev Mol Med       Date:  2009-01-28       Impact factor: 5.600

7.  A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis.

Authors:  Rongbao Zhao; Sang Hee Min; Yanhua Wang; Estela Campanella; Philip S Low; I David Goldman
Journal:  J Biol Chem       Date:  2008-12-11       Impact factor: 5.157

8.  The mechanism of 5-methyltetrahydrofolate transport by human erythrocytes.

Authors:  R F Branda; B K Anthony; H S Jacob
Journal:  J Clin Invest       Date:  1978-05       Impact factor: 14.808

9.  Phase I clinical trial and pharmacology of 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (metoprine) (DDMP) and folinic acid (CF).

Authors:  R de Jager; D Dupont; J J Rodzynek; C Dorlet; G Lagrange
Journal:  Cancer Chemother Pharmacol       Date:  1981       Impact factor: 3.333

10.  Partial purification and characterization of a folate-binding protein from human choroid plexus.

Authors:  S A Suleiman; R Spector; P Cancilla
Journal:  Neurochem Res       Date:  1981-03       Impact factor: 3.996
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.