| Literature DB >> 11671918 |
Queenie Xianghong Wang1, Jennifer King, Otto Phanstiel IV.
Abstract
Several primary amines (R-NH(2)) were converted to their corresponding O-benzoyl protected hydroxamates under biphasic conditions. The intermediate (benzoyloxy)amines (R-NHOCOPh) were generated using benzoyl peroxide dissolved in CH(2)Cl(2) and an aqueous carbonate buffer (pH 10.5) at room temperature. Subsequent acylation with R'COCl gave the protected hydroxamates (R'CONROCOPh) in good overall yields (56-89%).Entities:
Year: 1997 PMID： 11671918 DOI： 10.1021/jo971126q
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354