Literature DB >> 11669606

Interferon regulatory factor 7: a key cellular mediator of LMP-1 in EBV latency and transformation.

L Zhang1, J S Pagano.   

Abstract

Interferon regulatory factor 7 (IRF-7) was cloned within the biological context of Epstein-Barr virus (EBV) latency, and has an intimate relation with EBV. EBV latent membrane protein 1 (LMP-1) regulates IRF-7 both by inducing the expression of IRF-7 and by activating IRF-7 protein through phosphorylation and nuclear translocation in a post-translational manner. The activated IRF-7 then functions to regulate both EBV and cellular target genes involved in latency, transformation and immune regulation. IRF-7 appears to be a key cellular latency protein involved in both the pathogenesis and persistence of EBV infection. Copyright 2001 Academic Press.

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Year:  2001        PMID： 11669606     DOI： 10.1006/scbi.2001.0411

Source DB:  PubMed          Journal:  Semin Cancer Biol        ISSN： 1044-579X            Impact factor:   15.707


  17 in total

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4.  LMP1-Induced Sumoylation Influences the Maintenance of Epstein-Barr Virus Latency through KAP1.

Authors:  Gretchen L Bentz; Charles Randall Moss; Christopher B Whitehurst; Cary A Moody; Joseph S Pagano
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5.  Chimerically fused antigen rich of overlapped epitopes from latent membrane protein 2 (LMP2) of Epstein-Barr virus as a potential vaccine and diagnostic agent.

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9.  The Kaposi's Sarcoma-associated Herpesvirus-encoded vIRF-3 Inhibits Cellular IRF-5.

Authors:  Effi Wies; Alexander S Hahn; Katharina Schmidt; Cornelia Viebahn; Nadine Rohland; Anja Lux; Tim Schellhorn; Angela Holzer; Jae U Jung; Frank Neipel
Journal:  J Biol Chem       Date:  2009-01-07       Impact factor: 5.157

10.  Epstein-Barr Virus (EBV) Tegument Protein BGLF2 Suppresses Type I Interferon Signaling To Promote EBV Reactivation.

Authors:  XueQiao Liu; Tomohiko Sadaoka; Tammy Krogmann; Jeffrey I Cohen
Journal:  J Virol       Date:  2020-05-18       Impact factor: 5.103
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