Literature DB >> 11669604

EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes.

U Zimber-Strobl1, L J Strobl.   

Abstract

Epstein-Barr virus (EBV) has the ability to immortalize B cells. A viral key protein for immortalization is the transactivator EBNA2 that controls expression of several viral and cellular genes. EBNA2 is tethered to promoters by interacting with the cellular repressor RBP-J. This resembles the physiological activation of RBP-J-repressed promoters by activated Notch receptors (Notch-IC). Since EBNA2 and Notch-IC have been shown to be partially interchangeable in regard to activation of target genes in B cell lines and modulation of differentiation processes it is conceivable that EBNA2 is a biological equivalent of an activated Notch receptor. Copyright 2001 Academic Press.

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Year:  2001        PMID： 11669604     DOI： 10.1006/scbi.2001.0409

Source DB:  PubMed          Journal:  Semin Cancer Biol        ISSN： 1044-579X            Impact factor:   15.707


  39 in total

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Journal:  J Virol       Date:  2006-10       Impact factor: 5.103

4.  Dynamic chromatin boundaries delineate a latency control region of Epstein-Barr virus.

Authors:  Charles M Chau; Paul M Lieberman
Journal:  J Virol       Date:  2004-11       Impact factor: 5.103

5.  Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1.

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Review 6.  The viral etiology of AIDS-associated malignancies.

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7.  Asymmetric Arginine dimethylation of Epstein-Barr virus nuclear antigen 2 promotes DNA targeting.

Authors:  Henrik Gross; Stephanie Barth; Richard D Palermo; Alfredo Mamiani; Christine Hennard; Ursula Zimber-Strobl; Michelle J West; Elisabeth Kremmer; Friedrich A Grässer
Journal:  Virology       Date:  2009-12-06       Impact factor: 3.616

8.  Epstein-Barr virus nuclear antigen 2 trans-activates the cellular antiapoptotic bfl-1 gene by a CBF1/RBPJ kappa-dependent pathway.

Authors:  Pamela M Pegman; Sinéad M Smith; Brendan N D'Souza; Sinéad T Loughran; Sabine Maier; Bettina Kempkes; Paul A Cahill; Matthew J Simmons; Céline Gélinas; Dermot Walls
Journal:  J Virol       Date:  2006-08       Impact factor: 5.103

9.  Repression of the proapoptotic cellular BIK/NBK gene by Epstein-Barr virus antagonizes transforming growth factor β1-induced B-cell apoptosis.

Authors:  Eva M Campion; Roya Hakimjavadi; Sinéad T Loughran; Susan Phelan; Sinéad M Smith; Brendan N D'Souza; Rosemary J Tierney; Andrew I Bell; Paul A Cahill; Dermot Walls
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Review 10.  An Epigenetic Journey: Epstein-Barr Virus Transcribes Chromatinized and Subsequently Unchromatinized Templates during Its Lytic Cycle.

Authors:  Adityarup Chakravorty; Bill Sugden; Eric C Johannsen
Journal:  J Virol       Date:  2019-04-03       Impact factor: 5.103
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