| Literature DB >> 11667443 |
Debnath Bhuniya1, Arpita DattaGupta, Vinod K. Singh.
Abstract
The reaction of epoxides with chiral nonracemic lithium amide bases, designed and prepared from (R)-phenylglycine, has been studied in detail. A maximum of 80% ee was obtained for conversion of cyclohexene oxide to (S)-2-cyclohexen-1-ol. Enantioselective deprotonation of a variety of other epoxides was studied. A cyclopentanoid core unit for prostaglandin synthesis was synthesized in 97% ee.Entities:
Year: 1996 PMID： 11667443 DOI： 10.1021/jo960244v
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354