| Literature DB >> 1166306 |
R N Hill, T L Clemens, D K Liu, E S Vesell, W D Johnson.
Abstract
Mouse strain differences suggest intermediate or multifactorial gentic control of chloroform-induced renal toxicity and death. The chloroform dose lethal to 50 percent of animals was four times higher in C57BL/6J males than in DBA/2J males. Twice as much chloroform accumulated in the kidneys of the sensitive as the resistant strain. First generation offspring were midway between parental strains for both parameters.Entities:
Mesh：
Substances：
Year: 1975 PMID： 1166306 DOI： 10.1126/science.1166306
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728