Literature DB >> 1166305

Delivery of a quaternary pyridinium salt across the blood-brain barrier by its dihydropyridine derivative.

N Bodor, E Shek, T Higuchi.   

Abstract

A dihydropyridine-pyridine type redox system was successfully applied for delivering a quaternary pyridinium salt, N-methylpyridinium-2-aldoxime chloride (2-PAM), through the blood-brain barrier. The dihydropyridine derivative of 2-PAM was quickly oxidized to 2-PAM after crossing the blood-brain barrier. As a result of this approach, the brain cholinesterase blocked by organophosphates could be reactivated. The new method should be useful in delivering numerous drugs which are otherwise inaccessible to the brain because of their polar ionic character.

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Year:  1975        PMID： 1166305     DOI： 10.1126/science.1166305

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

Review 1.  CNS drug delivery: opioid peptides and the blood-brain barrier.

Authors:  Ken A Witt; Thomas P Davis
Journal:  AAPS J       Date:  2006-02-24       Impact factor: 4.009

2.  Chemotherapy administered in conjunction with osmotic blood-brain barrier modification in patients with brain metastases.

Authors:  E A Neuwelt; S A Dahlborg
Journal:  J Neurooncol       Date:  1987       Impact factor: 4.130

3.  Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure.

Authors:  Rakesh K Sit; Zrinka Kovarik; Nikolina Maček Hrvat; Suzana Žunec; Carol Green; Valery V Fokin; K Barry Sharpless; Zoran Radić; Palmer Taylor
Journal:  J Pharmacol Exp Ther       Date:  2018-09-06       Impact factor: 4.030

Review 4.  Prodrugs. Do they have advantages in clinical practice?

Authors:  V J Stella; W N Charman; V H Naringrekar
Journal:  Drugs       Date:  1985-05       Impact factor: 9.546

Review 5.  Drug transport across the blood-brain barrier. III. Mechanisms and methods to improve drug delivery to the central nervous system.

Authors:  J B Van Bree; A G De Boer; M Danhof; D D Breimer
Journal:  Pharm World Sci       Date:  1993-02-19

6.  "All in the mind"? Brain-targeting chemical delivery system of 17β-estradiol (Estredox) produces significant uterotrophic side effect.

Authors:  Katalin Prokai-Tatrai; Szabolcs Szarka; Vien Nguyen; Fatima Sahyouni; Cary Walker; Shastazia White; Tatjana Talamantes; Laszlo Prokai
Journal:  Pharm Anal Acta       Date:  2012

7.  New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases.

Authors:  Rakesh K Sit; Zoran Radić; Valeria Gerardi; Limin Zhang; Edzna Garcia; Maja Katalinić; Gabriel Amitai; Zrinka Kovarik; Valery V Fokin; K Barry Sharpless; Palmer Taylor
Journal:  J Biol Chem       Date:  2011-04-04       Impact factor: 5.157

Review 8.  A Historical Review of Brain Drug Delivery.

Authors:  William M Pardridge
Journal:  Pharmaceutics       Date:  2022-06-16       Impact factor: 6.525

9.  Pralidoxime iodide (2-pAM) penetrates across the blood-brain barrier.

Authors:  Koichi Sakurada; Kazuo Matsubara; Keiko Shimizu; Hiroshi Shiono; Yasuo Seto; Koichiro Tsuge; Mineo Yoshino; Ikuko Sakai; Harutaka Mukoyama; Takehiko Takatori
Journal:  Neurochem Res       Date:  2003-09       Impact factor: 3.996

Review 10.  Prodrugs for amines.

Authors:  Ana L Simplício; John M Clancy; John F Gilmer
Journal:  Molecules       Date:  2008-03-03       Impact factor: 4.411
  10 in total

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