Literature DB >> 1165794

Effects of concanavalin A on the isolated perfused rat liver.

R Kroker, D Hegner.   

Abstract

In the isolated perfused liver, Concanavalin A provoked a significant decrease of flow rate within 2 to 4 min. which was dose-dependent and could be partly inhibited by specific antagonists. Furthermore it was found that the lectin led to a decline of the respiration, an increase of the lactate/pyruvate ratio and a release of the transaminases into the medium. It was suggested that Concanavalin A displaced endothelial cells in the liver capillaries, which occluded the vessels and decreased the flow rate. The decreased respiration was considered to be secondary to this effect.

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Year:  1975        PMID： 1165794     DOI： 10.1007/bf00501306

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  18 in total

1.  Studies on the in vitro effects of insulin on glycogen synthesis and ultrastructure in isolated rat liver hepatocytes.

Authors:  S R Wagle; W R Ingebretsen; L Sampson
Journal:  Biochem Biophys Res Commun       Date:  1973-08-06       Impact factor: 3.575

2.  Interaction of concanavalin A and wheat germ agglutinin with the insulin receptor of fat cells and liver.

Authors:  P Cuatrecasas
Journal:  J Biol Chem       Date:  1973-05-25       Impact factor: 5.157

3.  [Studies on the mechanism of action of phalloidin. Release of lysosomal enzymes and potassium].

Authors:  M Frimmer; J Gries; D Hegner
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1967

4.  In vivo toxicity of concanavalin A.

Authors:  M L Tyan
Journal:  Proc Soc Exp Biol Med       Date:  1974-09

5.  Topography of membrane concanavalin A sites modified by proteolysis.

Authors:  G L Nicolson
Journal:  Nat New Biol       Date:  1972-10-18

6.  The microcirculatory hepatic unit.

Authors:  A M Rappaport
Journal:  Microvasc Res       Date:  1973-09       Impact factor: 3.514

7.  Binding of concanavalin A-sepharose to glycoproteins of liver microsomal membranes.

Authors:  L Winqvist; L C Eriksson; G Dallner
Journal:  FEBS Lett       Date:  1974-05-15       Impact factor: 4.124

8.  The effect of perfusate pH on respiration and glycolysis in the isolated rat liver perfused with an erythrocyte- and protein-free medium.

Authors:  P O Seglen
Journal:  Biochim Biophys Acta       Date:  1972-05-16

9.  On the presence of a concanavalin-A reactive coat over the endothelial aortic surface and its modifications during early experimental cholesterol atherogenesis in rabbits.

Authors:  G Weber; P Fabbrini; L Resi
Journal:  Virchows Arch A Pathol Pathol Anat       Date:  1973-06-29

10.  [Research on liver toxicity of nitrostigmine (Parathion, E 605) in the perfused rat liver].

Authors:  J W Gaaz; W Poser; W D Erdmann
Journal:  Arch Toxicol       Date:  1974       Impact factor: 5.153
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  3 in total

1.  Inhibition of hepatic uptake of bile acids by rifamycins.

Authors:  M S Anwer; R Kroker; D Hegner
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-03       Impact factor: 3.000

2.  The interaction of rifamycin SV with hepatic transport of taurocholic acid in the isolated perfused rat liver.

Authors:  R Kroker; M S Anwer; D Hegner
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-05       Impact factor: 3.000

3.  A compartmental model for hepatic transport of taurocholic acid in isolated perfused rat liver.

Authors:  R Kroker; M S Anwer; D Hegner
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-07       Impact factor: 3.000
  3 in total

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