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Literature DB >> 1165593

Adenovirus type 2 DNA replication. II. Termini of DNA replication.

R Schilling, B Weingärtner, E L Winnacker.

Abstract

Complete, mature adenovirus type 2 DNA molecules were isolated from virus-infected HeLa cells, pulse-labeled at 20 h postinfection in [3H]thymidine pulses shorter than the time necessary for one round of viral DNA replication. After digestion with the restriction endonucleases Eco RI, Hpa I, and Hind III, a temporal order of synthesis of different regions of the viral genome was established from the relative specific radioactivities in the restriction enzyme fragments. A comparison with the physical order of these fragments revealed the existence of two termini of DNA replication towards both the molecular right and left ends, respectively, of the viral chromosome.

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Year: 1975 PMID： 1165593 PMCID： PMC354734

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

20 in total

1. Termination sites for adenovirus type 2 DNA replication.

Authors: A Tolun; U Pettersson
Journal: J Virol Date: 1975-10 Impact factor: 5.103

2. Isolation and partial characterization of single-stranded adenoviral DNA produced during synthesis of adenovirus type 2 DNA.

Authors: G Lavelle; C Patch; G Khoury; J Rose
Journal: J Virol Date: 1975-10 Impact factor: 5.103

Adenovirus type 2 DNA replication. II. Termini of DNA replication.

1. Termination sites for adenovirus type 2 DNA replication.

2. Isolation and partial characterization of single-stranded adenoviral DNA produced during synthesis of adenovirus type 2 DNA.

3. Origins and termini of adenovirus type 2 DNA replication.

4. Cleavage maps of DNA from adenovirus types 2 and 5 by restriction endonucleases EcoRI and HpaI.

5. Linear intermediates in the replication of adenovirus DNA.

6. A circula DNA-protein complex from adenoviruses.

7. Intermediates in type 5 adenovirus DNA replication.

8. A restriction enzyme from Hemophilus influenzae. I. Purification and general properties.

9. Adenovirus DNA. I. Molecular weight and conformation.

10. Adenovirus type 2 DNA replication. I. Evidence for discontinuous DNA synthesis.

1. In vitro termination of adenovirus DNA synthesis by a soluble replication complex.

2. Structural analysis of viral replicative intermediates isolated from adenovirus type 2-infected HeLa cell nuclei.

3. Genome structure of incomplete particles of adenovirus.

4. Mitochondrial DNA synthesis in adenovirus type 2-infected HeLa cells.

5. Synthesis and processing of the precursor to the major core protein of adenovirus type 2.

6. Synthesis of defective viral DNA in HeLa cells infected with adenovirus type 3.

7. Bidirectional replication of adenovirus type 2 DNA.

8. Enzymatic properties of viral replication complexes isolated from adenovirus type 2-infected HeLa cell nuclei.

9. Initiation of adenovirus DNA replication does not occur via a hairpin mechanism.

10. Adenovirus type 5 DNA binding protein stimulates binding of DNA polymerase to the replication origin.