Literature DB >> 1164512

Haemoglobin Titusville: alpha94 Asp replaced by Asn. A new haemoglobin with a lowered affinity for oxygen.

R G Schneider, R J Atkins, T S Hosty, G Tomlin, R Casey, H Lehmann, P A Lorkin, K Nagai.   

Abstract

A new haemoglobin variant with a decreased oxygen affinity is described, in which the substitution, alpha 94 (G1) Asp replaced by Asn, affects the alpha1beta2 contact alpha1G1-beta2G4. The relevance of this variant to our understanding of the importance of the hydrogen bond between alpha1G1 and beta2G4 in Perutz's model of oxyhaemoglobin A is discussed.

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Year:  1975        PMID: 1164512

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  2 in total

Review 1.  Thalassemic hemoglobinopathies.

Authors:  M H Steinberg; J G Adams
Journal:  Am J Pathol       Date:  1983-12       Impact factor: 4.307

2.  Hemoglobin Titusville: a rare low oxygen affinity hemoglobinopathy.

Authors:  Senan John Yasar; Vivian Irene Ravn Berg; Asim Ahmad; Donald Doll
Journal:  Clin Case Rep       Date:  2017-05-11
  2 in total

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