Literature DB >> 11641414

Positive allosteric modulators for gamma-aminobutyric acid(B) receptors open new routes for the development of drugs targeting family 3 G-protein-coupled receptors.

J P Pin1, M L Parmentier, L Prézeau.   

Abstract

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Year:  2001        PMID： 11641414     DOI： 10.1124/mol.60.5.881

Source DB:  PubMed          Journal:  Mol Pharmacol        ISSN： 0026-895X            Impact factor:   4.436


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  6 in total

1.  The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor.

Authors:  Virginie Binet; Carole Brajon; Laurent Le Corre; Francine Acher; Jean-Philippe Pin; Laurent Prézeau
Journal:  J Biol Chem       Date:  2004-05-04       Impact factor: 5.157

2.  GABA(B) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area.

Authors:  Ying Chen; Keith Phillips; Gareth Minton; Emanuele Sher
Journal:  Br J Pharmacol       Date:  2005-04       Impact factor: 8.739

3.  Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI.

Authors:  Joseph E Pero; Michael A Rossi; Michael J Kelly; Hannah D G F Lehman; Mark E Layton; Robert M Garbaccio; Julie A O'Brien; Brian C Magliaro; Jason M Uslaner; Sarah L Huszar; Kerry L Fillgrove; Cuyue Tang; Yuhsin Kuo; Leo A Joyce; Edward C Sherer; Marlene A Jacobson
Journal:  ACS Med Chem Lett       Date:  2016-01-10       Impact factor: 4.345

4.  Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor.

Authors:  Robert M Garbaccio; Edward J Brnardic; Mark E Fraley; George D Hartman; Pete H Hutson; Julie A O'Brien; Brian C Magliaro; Jason M Uslaner; Sarah L Huszar; Kerry L Fillgrove; James H Small; Cuyue Tang; Yuhsin Kuo; Marlene A Jacobson
Journal:  ACS Med Chem Lett       Date:  2010-07-12       Impact factor: 4.345

5.  Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives.

Authors:  Zhan-Guo Gao; Seong Gon Kim; Kelly A Soltysiak; Neli Melman; Adriaan P IJzerman; Kenneth A Jacobson
Journal:  Mol Pharmacol       Date:  2002-07       Impact factor: 4.436

6.  Exploring Conformational Dynamics of the Extracellular Venus flytrap Domain of the GABAB Receptor: A Path-Metadynamics Study.

Authors:  Linn S M Evenseth; Riccardo Ocello; Mari Gabrielsen; Matteo Masetti; Maurizio Recanatini; Ingebrigt Sylte; Andrea Cavalli
Journal:  J Chem Inf Model       Date:  2020-04-15       Impact factor: 4.956
  6 in total

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