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Literature DB >> 116281

Stimulation of human prolactin secretion by mescaline.

Abstract

Prolactin (PRL) and Growth Hormone (GH) secretions were studied in human serum after the oral administration of 5 mg/kg mescaline (3,4,5-trimethoxy-beta-phenylethylamine) or 2,3,4-trimethoxy-beta-phenylethylamine (2,3,4-TMPEA) respectively. Mescaline stimulated the secretion of PRL more than four-fold above base-line levels. Peak concentrations were found 90--120 min after drug intake. Five hours later serum PRL was still markedly increased. Mescaline also triggered GH secretion. There was no alteration of serum PRL and GH concentrations after intake of the non-hallucinogenic 2,3,4-TMPEA.

Entities: Chemical Gene Species

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Year: 1979 PMID： 116281 DOI： 10.1007/bf00427525

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

17 in total

1. Effects of LSD-25 on brain serotonin.

Authors: D X FREEDMAN
Journal: J Pharmacol Exp Ther Date: 1961-11 Impact factor: 4.030

2. Antagonism between lysergic acid diethylamide and 5-hydroxytryptamine.

Authors: J H GADDUM
Journal: J Physiol Date: 1953-07 Impact factor: 5.182

3. A BIOCHEMICAL AND PHARMACOLOGICAL SUGGESTION ABOUT CERTAIN MENTAL DISORDERS.

Authors: D W Woolley; E Shaw
Journal: Proc Natl Acad Sci U S A Date: 1954-04 Impact factor: 11.205

4. Effect of 5,6-dihydroxytryptamine on the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam in mice.

Authors: M Nakamura; H Fukushima
Journal: J Pharm Pharmacol Date: 1978-01 Impact factor: 3.765

5. Hallucinogenic phenylethylamines: interactions with serotonin turnover and receptors.

Authors: N E Andén; H Corrodi; K Fuxe; J L Meek
Journal: Eur J Pharmacol Date: 1974-02 Impact factor: 4.432

6. Oxidative metabolism of mescaline in the central nervous system. II. Oxidative deamination of mescaline and 2,3,4-trimethoxy-beta-phenylethylamine by different mouse brain area in vitro.

Authors: N Seiler; L Demisch
Journal: Biochem Pharmacol Date: 1971-09 Impact factor: 5.858

Stimulation of human prolactin secretion by mescaline.

1. Effects of LSD-25 on brain serotonin.

2. Antagonism between lysergic acid diethylamide and 5-hydroxytryptamine.

3. A BIOCHEMICAL AND PHARMACOLOGICAL SUGGESTION ABOUT CERTAIN MENTAL DISORDERS.

4. Effect of 5,6-dihydroxytryptamine on the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam in mice.

5. Hallucinogenic phenylethylamines: interactions with serotonin turnover and receptors.

6. Oxidative metabolism of mescaline in the central nervous system. II. Oxidative deamination of mescaline and 2,3,4-trimethoxy-beta-phenylethylamine by different mouse brain area in vitro.

7. Blockade of the stimulus properties of mescaline by a serotonin antagonist.

8. The discriminative stimulus properties of LSD: mechanisms of action.

9. Stimulation of rat prolactin secretion by indolealkylamine hallucinogens.

10. Evidence for a central 5-hydroxytryptamine receptor stimulation by lysergic acid diethylamide.

Review 1. Drug-induced changes in prolactin secretion. Clinical implications.