| Literature DB >> 11606364 |
P Iughetti1, O Suzuki, P H Godoi, V A Alves, A L Sertié, T Zorick, F Soares, A Camargo, E S Moreira, C di Loreto, C A Moreira-Filho, A Simpson, G Oliva, M R Passos-Bueno.
Abstract
We have performed association studies between a novel coding single nucleotide polymorphism (D104N) in endostatin, one of the most potent inhibitors of angiogenesis, and prostate cancer. We observed that heterozygous N104 individuals have a 2.5 times increased chance of developing prostate cancer as compared with homozygous D104 subjects (odds ratio, 2.4; 95% confidence interval, 1.4-4.16). Modeling of the endostatin mutant showed that the N104 protein is stable. These results together with the observation that residue 104 is evolutionary conserved lead us to propose that: (a) the DNA segment containing this residue might contain a novel interaction site to a yet unknown receptor; and (b) the presence of N104 impairs the function of endostatin.Entities:
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Year: 2001 PMID： 11606364
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701