Literature DB >> 11606118

Rapid enantiomeric quantification of an antiviral nucleoside agent (D,L-FMAU, 2'-fluoro-5-methyl-beta,D,L-arabinofurano-syluracil) by mass spectrometry.

W A Tao, L Wu, R G Cooks, F Wang, J A Begley, B Lampert.   

Abstract

A novel mass spectrometric method is applied to rapid, accurate (<1%) quantification of chiral Clevudine (L-FMAU, 2'-fluoro-5-methyl-beta,L-arabinofuranosyluracil), a potent antiviral nucleoside agent against hepatitis B virus. Transition metal bound complex ions containing the chiral drug are generated by electrospray ionization mass spectrometry and subjected to collision-induced dissociation. The ratio of the two competitive dissociation rates is related to the enantiomeric composition of the drug mixture, allowing the determination of enantiomeric contamination in the drug.

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Year:  2001        PMID： 11606118     DOI： 10.1021/jm0155547

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  8 in total

1.  Evaluation of chiral recognition characteristics of metal and proton complexes of di-o-benzoyl-tartaric acid dibutyl ester and L-tryptophan in the gas phase.

Authors:  Hao-Jie Lu; Yin-Long Guo
Journal:  J Am Soc Mass Spectrom       Date:  2003-06       Impact factor: 3.109

2.  Isomeric distinction of small oligosaccharides: a bottom-up approach using the kinetic method.

Authors:  Mohamed Major; Thierry Fouquet; Laurence Charles
Journal:  J Am Soc Mass Spectrom       Date:  2011-04-09       Impact factor: 3.109

3.  A study on the interaction between 5-Methyluridine and human serum albumin using fluorescence quenching method and molecular modeling.

Authors:  Feng-Ling Cui; Ying-Hua Yan; Qiang-Zhai Zhang; Gui-Rong Qu; Juan Du; Xiao-Jun Yao
Journal:  J Mol Model       Date:  2009-07-09       Impact factor: 1.810

4.  Recognition and quantification of binary and ternary mixtures of isomeric peptides by the kinetic method: metal ion and ligand effects on the dissociation of metal-bound complexes.

Authors:  Lianming Wu; Karel Lemr; Tenna Aggerholm; R Graham Cooks
Journal:  J Am Soc Mass Spectrom       Date:  2003-02       Impact factor: 3.109

5.  Chiral recognition of zinc(II) ion complexes composed of bicyclo[3.3.0] octane-2,6-diol and s-naproxen probed by collisional-induced dissociation.

Authors:  Chong-Tian Yu; Yin-Long Guo; Guo-Qiang Chen; Yu-Wu Zhong
Journal:  J Am Soc Mass Spectrom       Date:  2004-06       Impact factor: 3.109

6.  Stereoselectivity in the collision-activated reactions of gas phase salt complexes.

Authors:  Scott Gronert; Adelaide E Fagin; Keiko Okamoto
Journal:  J Am Soc Mass Spectrom       Date:  2004-10       Impact factor: 3.109

7.  Structural relationships in small molecule interactions governing gas-phase enantioselectivity and zwitterionic formation.

Authors:  Xin Cong; Gregg Czerwieniec; Erica McJimpsey; Seonghee Ahn; Frederic A Troy; Carlito B Lebrilla
Journal:  J Am Soc Mass Spectrom       Date:  2006-02-14       Impact factor: 3.109

8.  Chiral discrimination of D- and L-amino acids using iodinated tyrosines as chiral references: effect of iodine substituent.

Authors:  Sangeeta Kumari; Sripadi Prabhakar; Mariappanadar Vairamani; Chebrolu Lavanya Devi; Gunturu Krishna Chaitanya; Kotamarthi Bhanuprakash
Journal:  J Am Soc Mass Spectrom       Date:  2007-05-17       Impact factor: 3.109
  8 in total

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