Literature DB >> 11605676

Novel neuronal nitric oxide synthase (nNOS) selective inhibitor, aplysinopsin-type indole alkaloid, from marine sponge Hyrtios erecta.

S Aoki1, Y Ye, K Higuchi, A Takashima, Y Tanaka, I Kitagawa, M Kobayashi.   

Abstract

Two novel aplysinopsin-type indole alkaloids, 1 and 2, and three known indole alkaloids were isolated from the marine sponge Hyrtios erecta. These compounds exhibited selective inhibitory activity against the neuronal isozyme of nitric oxide synthase (nNOS). Furthermore, new quinolone 7 was also isolated from the same marine sponge. The chemical structures of these new compounds were elucidated on the basis of spectroscopic analysis.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11605676     DOI： 10.1248/cpb.49.1372

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  13 in total

Review 1.  Marine indole alkaloids: potential new drug leads for the control of depression and anxiety.

Authors:  Anna J Kochanowska-Karamyan; Mark T Hamann
Journal:  Chem Rev       Date:  2010-08-11       Impact factor: 60.622

2.  Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes.

Authors:  David F Cummings; Diana C Canseco; Pratikkumar Sheth; James E Johnson; John A Schetz
Journal:  Bioorg Med Chem       Date:  2010-05-15       Impact factor: 3.641

Review 3.  Aplysinopsins--marine indole alkaloids: chemistry, bioactivity and ecological significance.

Authors:  Dobroslawa Bialonska; Jordan K Zjawiony
Journal:  Mar Drugs       Date:  2009-05-19       Impact factor: 5.118

Review 4.  Halogenated indole alkaloids from marine invertebrates.

Authors:  Patrícia Mendonça Pauletti; Lucas Silva Cintra; Caio Guedes Braguine; Ademar Alves da Silva Filho; Márcio Luís Andrade E Silva; Wilson Roberto Cunha; Ana Helena Januário
Journal:  Mar Drugs       Date:  2010-04-28       Impact factor: 5.118

Review 5.  Recent advances toward improving the bioavailability of neuronal nitric oxide synthase inhibitors.

Authors:  He Huang; Richard B Silverman
Journal:  Curr Top Med Chem       Date:  2013       Impact factor: 3.295

Review 6.  Marine invertebrate natural products for anti-inflammatory and chronic diseases.

Authors:  Kalimuthu Senthilkumar; Se-Kwon Kim
Journal:  Evid Based Complement Alternat Med       Date:  2013-12-31       Impact factor: 2.629

7.  Antiproliferative Scalarane-Based Metabolites from the Red Sea Sponge Hyrtios erectus.

Authors:  Sameh S Elhady; Ahmed M Al-Abd; Ali M El-Halawany; Abdulrahman M Alahdal; Hashim A Hassanean; Safwat A Ahmed
Journal:  Mar Drugs       Date:  2016-07-08       Impact factor: 5.118

8.  Merosesquiterpene Congeners from the Australian Sponge Hyrtios digitatus as Potential Drug Leads for Atherosclerosis Disease.

Authors:  Huda A Wahab; Ngoc B Pham; Tengku S Tengku Muhammad; John N A Hooper; Ronald J Quinn
Journal:  Mar Drugs       Date:  2016-12-27       Impact factor: 5.118

9.  4-Hydroxy-3-methyl-2(1H)-quinolone, originally discovered from a Brassicaceae plant, produced by a soil bacterium of the genus Burkholderia sp.: determination of a preferred tautomer and antioxidant activity.

Authors:  Dandan Li; Naoya Oku; Yukiko Shinozaki; Yoichi Kurokawa; Yasuhiro Igarashi
Journal:  Beilstein J Org Chem       Date:  2020-06-26       Impact factor: 2.883

10.  Bioactive compounds from the Red Sea marine sponge Hyrtios species.

Authors:  Diaa T A Youssef; Lamiaa A Shaala; Hani Z Asfour
Journal:  Mar Drugs       Date:  2013-03-28       Impact factor: 5.118
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.