Literature DB >> 11605670

Alkylation of 2-phenyl-4-quinolones: synthetic and structural studies.

M Hadjeri1, A M Mariotte, A Boumendjel.   

Abstract

The alkylation of 2-phenyl-4-quinolones was investigated and showed that the N-alkylation versus O-alkylation is highly dependent on whether C-5 is hydroxylated or not. N-Alkylation is favoured by the presence of a 5-hydroxyl group. The synthetic and the NMR structural studies are reported.

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Year:  2001        PMID： 11605670     DOI： 10.1248/cpb.49.1352

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  2 in total

1.  Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity.

Authors:  Mostafa M Elbadawi; Wagdy M Eldehna; Wenjie Wang; Keli K Agama; Yves Pommier; Manabu Abe
Journal:  Eur J Med Chem       Date:  2021-02-09       Impact factor: 7.088

2.  Direct one-pot synthesis of primary 4-amino-2,3-diaryl-quinolines via Suzuki-Miyaura cross-coupling of 2-aryl-4-azido-3-iodoquinolines with arylboronic acids.

Authors:  Malose Jack Mphahlele; Mamasegare Mabel Mphahlele
Journal:  Molecules       Date:  2011-10-25       Impact factor: 4.411
  2 in total

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