| Literature DB >> 11604984 |
J Perrin1, J Gouvernet, D Parriaux, T Noguchi, M H Giovannini, M Giovannini, J R Delpero, D Birnbaum, G Monges.
Abstract
MSH2 and MLH1 are proteins involved in DNA reparation. They are mutated in some forms of colon cancer, i.e. hereditary non-polyposis carcinomas and a subset of sporadic carcinomas. We have studied the expression of MSH2 and MLH1 in a retrospective series of 225 colorectal carcinomas by immunohistochemistry. The results were compared to molecular tests of microsatellite instability using amplification by PCR of BAT-25 and BAT-26 repeated sequences and to histoclinical data. Positivity of both proteins was never associated with MSI phenotype. MSH2 and/or MLH1 negative tumors were frequently tumors of the proximal colon; in this subpopulation or proximal tumors, MSH2 and/or MLH1 negativity was associated with a longer disease-free survival.Entities:
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Year: 2001 PMID： 11604984 DOI： 10.3892/ijo.19.5.891
Source DB: PubMed Journal: Int J Oncol ISSN： 1019-6439 Impact factor: 5.650