Literature DB >> 11600388

Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin B.

M Gottfredsson1, C J Jessup, G M Cox, J R Perfect, M A Ghannoum.   

Abstract

It has been postulated that phospholipases of fungal origin can affect in vitro susceptibility testing of amphotericin B lipid complex (ABLC). We used specific phospholipase-deficient mutants of Candida albicans and Cryptococcus neoformans in susceptibility testing and demonstrated that extracellular fungal phospholipase activity does not influence the in vitro susceptibilities of these two fungi to ABLC.

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Year:  2001        PMID： 11600388      PMCID： PMC90814          DOI： 10.1128/AAC.45.11.3231-3233.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  5 in total

1.  In vitro and in vivo antifungal activity of amphotericin B lipid complex: are phospholipases important?

Authors:  C E Swenson; W R Perkins; P Roberts; I Ahmad; R Stevens; D A Stevens; A S Janoff
Journal:  Antimicrob Agents Chemother       Date:  1998-04       Impact factor: 5.191

Review 2.  Potential role of phospholipases in virulence and fungal pathogenesis.

Authors:  M A Ghannoum
Journal:  Clin Microbiol Rev       Date:  2000-01       Impact factor: 26.132

3.  Identification of extracellular phospholipase B, lysophospholipase, and acyltransferase produced by Cryptococcus neoformans.

Authors:  S C Chen; L C Wright; R T Santangelo; M Muller; V R Moran; P W Kuchel; T C Sorrell
Journal:  Infect Immun       Date:  1997-02       Impact factor: 3.441

4.  Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans.

Authors:  G M Cox; H C McDade; S C Chen; S C Tucker; M Gottfredsson; L C Wright; T C Sorrell; S D Leidich; A Casadevall; M A Ghannoum; J R Perfect
Journal:  Mol Microbiol       Date:  2001-01       Impact factor: 3.501

5.  Cloning and disruption of caPLB1, a phospholipase B gene involved in the pathogenicity of Candida albicans.

Authors:  S D Leidich; A S Ibrahim; Y Fu; A Koul; C Jessup; J Vitullo; W Fonzi; F Mirbod; S Nakashima; Y Nozawa; M A Ghannoum
Journal:  J Biol Chem       Date:  1998-10-02       Impact factor: 5.157
  5 in total
  2 in total

Review 1.  Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients.

Authors:  Romuald Bellmann; Piotr Smuszkiewicz
Journal:  Infection       Date:  2017-07-12       Impact factor: 3.553

Review 2.  Amphotericin B formulations: a comparative review of efficacy and toxicity.

Authors:  Richard J Hamill
Journal:  Drugs       Date:  2013-06       Impact factor: 9.546
  2 in total

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