Literature DB >> 11600237

Synthesis of some triazolyl-antipyrine derivatives and investigation of analgesic activity.

G Turan-Zitouni1, M Sivaci, F S Kiliç, K Erol.   

Abstract

The synthesis of some triazolyl-antipyrine derivatives starting from 4-chloroacetamidoantipyrine and 3-(aryloxyalkyl)-4-ethyl/phenyl-5-mercapto-1,2,4-triazoles is described. The chemical structures of the compounds were elucidated by IR, 1H-NMR and mass spectral studies. These compounds were tested for analgesic activity.

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Year:  2001        PMID： 11600237     DOI： 10.1016/s0223-5234(01)01252-1

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  10 in total

1.  Synthesis of new bis-1,2,4-triazole derivatives.

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2.  Synthesis, Spectral Characterization, DNA/ Protein Binding, DNA Cleavage, Cytotoxicity, Antioxidative and Molecular Docking Studies of Cu(II)Complexes Containing Schiff Base-bpy/Phen Ligands.

Authors:  Berelli Anupama; Airva Aruna; Vijjulatha Manga; Sreekanth Sivan; Madamsetty Vijay Sagar; Ravula Chandrashekar
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3.  Antinociceptive effects of gabapentin & its mechanism of action in experimental animal studies.

Authors:  Fatma Sultan Kilic; Basar Sirmagul; Engin Yildirim; Setenay Oner; Kevser Erol
Journal:  Indian J Med Res       Date:  2012-05       Impact factor: 2.375

4.  4-[(1-Hy-droxy-2-naphth-yl)methyl-ene-amino]-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one.

Authors:  Qiang Liang; Qian Wang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-07-10

5.  Anti-inflammatory and antinociceptive evaluation of newly synthesized 4-(substituted ethanoyl) amino-3-mercapto-5-(4-methoxy) phenyl-1,2,4-triazoles.

Authors:  Neeraj Upmanyu; Jeetendra Kumar Gupta; Kamal Shah; Pradeep Mishra
Journal:  J Pharm Bioallied Sci       Date:  2011-04

6.  Synthesis, characterization and anti-breast cancer activity of new 4-aminoantipyrine-based heterocycles.

Authors:  Mostafa M Ghorab; Marwa G El-Gazzar; Mansour S Alsaid
Journal:  Int J Mol Sci       Date:  2014-05-02       Impact factor: 5.923

7.  Synthesis and biological activities of 4-aminoantipyrine derivatives derived from betti-type reaction.

Authors:  Ipsita Mohanram; Jyotsna Meshram
Journal:  ISRN Org Chem       Date:  2014-03-04

8.  Understanding the enzymatic inhibition of intestinal alkaline phosphatase by aminophenazone-derived aryl thioureas with aided computational molecular dynamics simulations: synthesis, characterization, SAR and kinetic profiling.

Authors:  Asma Khurshid; Aamer Saeed; Zaman Ashraf; Qamar Abbas; Mubashir Hassan
Journal:  Mol Divers       Date:  2020-08-29       Impact factor: 2.943

9.  Assessment of genetic integrity, splenic phagocytosis and cell death potential of (Z)-4-((1,5-dimethyl-3-oxo-2-phenyl-2,3dihydro-1H-pyrazol-4-yl) amino)-4-oxobut-2-enoic acid and its effect when combined with commercial chemotherapeutics.

Authors:  Rodrigo Juliano Oliveira; Naiara da Cruz Leite Santos; João Renato Pesarini; Beatriz Carneiro de Oliveira; Claudia Rodrigues Berno; Flávio Henrique Souza de Araújo; Ingridhy Ostaciana Maia Freitas da Silveira; Raquel Oliveira Nascimento; Andréia Conceição Milan Brochado Antoniolli-Silva; Antônio Carlos Duenhas Monreal; Adilson Beatriz; Dênis Pires de Lima; Roberto da Silva Gomes
Journal:  Genet Mol Biol       Date:  2018-02-19       Impact factor: 1.771

10.  Coordination modes of a schiff base pentadentate derivative of 4-aminoantipyrine with cobalt(II), nickel(II) and copper(II) metal ions: synthesis, spectroscopic and antimicrobial studies.

Authors:  Sulekh Chandra; Deepali Jain; Amit Kumar Sharma; Pratibha Sharma
Journal:  Molecules       Date:  2009-01-01       Impact factor: 4.411
  10 in total

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