L Shen1, Y Cui. 1. Beijing Municipal Institute for Drug Control, Beijing 100035.
Abstract
OBJECTIVE: To observe the effects of the leaf of Ginkgo biloba extract(GBE) on viscosity and elasticity, coagulation of blood and aggregation of blood platelets. METHOD: The viscosity and elasticity of the whole blood in rats was determined using an in vitro method. The half inhibitory concentration of the drug inhibiting rabbit platelet aggregation was also determined using ADP as an inducer. The blood coagulation in mice was recorded with a coagulation analyser after GBE was administered by vein injection. RESULT: GBE significantly lengthened the recalcium time, lowered the increase ratios of viscosity and elasticity, and reduced the maximum viscosity and elasticity. At doses of 100 and 200 mg/kg administrated by vein injection GBE lengthened the coagulation time, reduced the fibriogenesis and clot retraction ratio significantly in mice. GBE can also inhibit rabbit platelet aggregation induced by ADP and promote the disband of the aggregated platelets. CONCLUSION: GBE is helpful in reducing viscosity and elasticity of the whole blood, slowing blood coagulation and inhibiting platelet aggregation.
OBJECTIVE: To observe the effects of the leaf of Ginkgo biloba extract(GBE) on viscosity and elasticity, coagulation of blood and aggregation of blood platelets. METHOD: The viscosity and elasticity of the whole blood in rats was determined using an in vitro method. The half inhibitory concentration of the drug inhibiting rabbit platelet aggregation was also determined using ADP as an inducer. The blood coagulation in mice was recorded with a coagulation analyser after GBE was administered by vein injection. RESULT: GBE significantly lengthened the recalcium time, lowered the increase ratios of viscosity and elasticity, and reduced the maximum viscosity and elasticity. At doses of 100 and 200 mg/kg administrated by vein injection GBE lengthened the coagulation time, reduced the fibriogenesis and clot retraction ratio significantly in mice. GBE can also inhibit rabbit platelet aggregation induced by ADP and promote the disband of the aggregated platelets. CONCLUSION: GBE is helpful in reducing viscosity and elasticity of the whole blood, slowing blood coagulation and inhibiting platelet aggregation.