Literature DB >> 11597818

Different effects of antipsychotic drugs on insulin release in vitro.

K Melkersson1, A Khan, A Hilding, A L Hulting.   

Abstract

The aim of this study was to examine the influence of antipsychotic drugs on insulin release from pancreatic beta cells in vitro. The effect of seven antipsychotics (i.e. chlorpromazine, haloperidol, perphenazine, zuclopenthixol, clozapine, olanzapine and risperidone) in a concentration of 10(-6) M was investigated on basal and glucose-stimulated insulin release. Clozapine increased basal insulin release, whereas haloperidol inhibited glucose-stimulated release and the other five antipsychotics had no significant effects. A possible stimulatory effect of clozapine on insulin release may explain its ability to increase appetite and induce weight gain.

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Year:  2001        PMID： 11597818     DOI： 10.1016/s0924-977x(01)00108-0

Source DB:  PubMed          Journal:  Eur Neuropsychopharmacol        ISSN： 0924-977X            Impact factor:   4.600


  14 in total

Review 1.  [Antipsychotic drug-induced changes in metabolism].

Authors:  Julia Engl; Alexander Tschoner; Markus Laimer; Maria Rettenbacher; W Wolfgang Fleischhacker; Josef R Patsch; Christoph Ebenbichler
Journal:  Wien Klin Wochenschr       Date:  2006-05       Impact factor: 1.704

2.  Pharmacological modulation of dopamine receptor D2-mediated transmission alters the metabolic phenotype of diet induced obese and diet resistant C57Bl6 mice.

Authors:  J E de Leeuw van Weenen; E T Parlevliet; J P Schröder-van der Elst; S A van den Berg; K Willems van Dijk; J A Romijn; H Pijl
Journal:  Exp Diabetes Res       Date:  2011-04-06

3.  The atypical antipsychotic clozapine impairs insulin secretion by inhibiting glucose metabolism and distal steps in rat pancreatic islets.

Authors:  N Sasaki; M Iwase; Y Uchizono; U Nakamura; H Imoto; S Abe; M Iida
Journal:  Diabetologia       Date:  2006-10-27       Impact factor: 10.122

4.  Profile of olanzapine long-acting injection for the maintenance treatment of adult patients with schizophrenia.

Authors:  Rosaria Di Lorenzo; Alice Brogli
Journal:  Neuropsychiatr Dis Treat       Date:  2010-09-07       Impact factor: 2.570

5.  Relationship between levels of insulin or triglycerides and serum concentrations of the atypical antipsychotics clozapine and olanzapine in patients on treatment with therapeutic doses.

Authors:  K I Melkersson; M-L Dahl
Journal:  Psychopharmacology (Berl)       Date:  2003-07-08       Impact factor: 4.530

6.  Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro.

Authors:  Norman Simpson; Antonella Maffei; Matthew Freeby; Steven Burroughs; Zachary Freyberg; Jonathan Javitch; Rudolph L Leibel; Paul E Harris
Journal:  Mol Endocrinol       Date:  2012-08-21

Review 7.  Guidelines for prevention and treatment of adverse effects of antipsychotic drugs on glucose-insulin homeostasis and lipid metabolism.

Authors:  K I Melkersson; M-L Dahl; A-L Hulting
Journal:  Psychopharmacology (Berl)       Date:  2004-06-25       Impact factor: 4.530

Review 8.  Adverse metabolic effects associated with atypical antipsychotics: literature review and clinical implications.

Authors:  Kristina Melkersson; Marja-Liisa Dahl
Journal:  Drugs       Date:  2004       Impact factor: 9.546

Review 9.  Immunomodulatory Effects Mediated by Dopamine.

Authors:  Rodrigo Arreola; Samantha Alvarez-Herrera; Gilberto Pérez-Sánchez; Enrique Becerril-Villanueva; Carlos Cruz-Fuentes; Enrique Octavio Flores-Gutierrez; María Eugenia Garcés-Alvarez; Dora Luz de la Cruz-Aguilera; Emilio Medina-Rivero; Gabriela Hurtado-Alvarado; Saray Quintero-Fabián; Lenin Pavón
Journal:  J Immunol Res       Date:  2016-10-04       Impact factor: 4.818

10.  Life-threatening hypoglycemia attributable to haloperidol in a patient with schizophrenia.

Authors:  Joana Couto; Luís Pontes Dos Santos; Tiago Mendes; Raquel López
Journal:  Braz J Psychiatry       Date:  2019 Mar-Apr       Impact factor: 2.697
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