| Literature DB >> 11597413 |
R Lavoie1, G Bouchain, S Frechette, S H Woo, E Abou-Khalil, S Leit, M Fournel, P T Yan, M C Trachy-Bourget, C Beaulieu, Z Li, J Besterman, D Delorme.
Abstract
Histone deacetylase inhibitors (HDACs) have emerged as a novel class of antiproliferative agents. Utilizing structure-based design, the synthesis of a series of sulfonamide hydroxamic acids is described. Further optimization of this series by substitution of the terminal aromatic ring yielded HDAC inhibitors with good in vitro and in vivo activities.Entities:
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Year: 2001 PMID： 11597413 DOI： 10.1016/s0960-894x(01)00552-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823