| Literature DB >> 11597412 |
S M Bromidge1, K Griffith, T D Heightman, A Jennings, F D King, S F Moss, H Newman, G Riley, C Routledge, H T Serafinowska, D R Thomas.
Abstract
The discovery of (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides and their binding affinities for a selection of 5-HT and dopamine subreceptors is described. Many compounds show high affinity (pK(i)>8) for the 5-HT(6) receptor and >100-fold selectivity against a range of other receptors. Structure-activity relationships of these compounds are discussed.Entities:
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Year: 2001 PMID： 11597412 DOI： 10.1016/s0960-894x(01)00558-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823