Literature DB >> 1159712

Studies in potential filaricides. 6. Synthesis of 3,8-disubstituted 1,3,8-triazabicyclo(4.4.0)decan-2-ones and -thiones.

S Sharma, R Bindra, R N Iyer, N Anand.   

Abstract

1,3,8-Triazabicyclo[4.4.0]decan-2-ones and -thiones varying substituents at positions 3 and 8 have been synthesized. When tested in cotton rats for their antifilarial activity against Litomosoides carinii, some of the compounds showed moderate microfilaricidal activity.

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Year:  1975        PMID: 1159712     DOI: 10.1021/jm00243a011

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  1 in total

1.  Treatment of filariasis-diethylcarbamazine and its congeners.

Authors:  S Sharma
Journal:  Pharm Res       Date:  1986-04       Impact factor: 4.200

  1 in total

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