| Literature DB >> 1159574 |
M F Dixon, B Dixon, S R Aparicio, D P Loney.
Abstract
Rats were killed at various time-intervals up to 48 hr after a single large dose of paracetamol (3 g per kg) and their livers examined by light and electron microscopy. In general, this revealed glycogen depletion, loss of ribosomes, and cytoplasmic matrix swelling commencing 3-6 hr after administration which in centrilobular hepatocytes progressed to frank coagulative necrosis at 12-24 hr. Midzonal cells showed more prominent aqueous swelling with besiculation of the endoplasmic reticulum, and in some cells, gross hydropic vacuolation.Entities:
Mesh：
Substances：
Year: 1975 PMID： 1159574 DOI： 10.1002/path.1711160104
Source DB: PubMed Journal: J Pathol ISSN： 0022-3417 Impact factor: 7.996