Literature DB >> 1159566

Melanosis coli: studies of the toxic effects of irritant purgatives.

H W Steer, D G Colin-Jones.   

Abstract

Colonic biopsies from six patients with normal colons and seven patients with melanosis coli were studied ultrastructurally and histochemically for lysosomal enzymes. Anthraquinone purgatives were found to increase the number of macrophages in the connective tissue of the colonic mucosa. In addition, they cause an increase in the intensity of lysosomal activity and an increase in the number of lysosomes in macrophages, Schwann cells and neurones of the submucosal plexus of the colonic mucosa.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 1159566     DOI： 10.1002/path.1711150403

Source DB:  PubMed          Journal:  J Pathol        ISSN： 0022-3417            Impact factor:   7.996


  10 in total

Review 1.  What has happened to the cathartic colon?

Authors:  S Müller-Lissner
Journal:  Gut       Date:  1996-09       Impact factor: 23.059

2.  Anthranoid laxative abuse--a risk for colorectal cancer?

Authors:  C P Siegers; E von Hertzberg-Lottin; M Otte; B Schneider
Journal:  Gut       Date:  1993-08       Impact factor: 23.059

3.  Colorectal neoplasms in melanosis coli: a survey in Japan and a worldwide meta-analysis.

Authors:  Ryo Katsumata; Noriaki Manabe; Minoru Fujita; Maki Ayaki; Aya Sunago; Tomoari Kamada; Yasumasa Monobe; Hirofumi Kawamoto; Ken Haruma
Journal:  Int J Colorectal Dis       Date:  2021-06-22       Impact factor: 2.571

Review 4.  Adverse effects of drugs used in the management of constipation and diarrhoea.

Authors:  J M Gattuso; M A Kamm
Journal:  Drug Saf       Date:  1994-01       Impact factor: 5.606

5.  Melanosis coli. A consequence of anthraquinone-induced apoptosis of colonic epithelial cells.

Authors:  N I Walker; R E Bennett; R A Axelsen
Journal:  Am J Pathol       Date:  1988-06       Impact factor: 4.307

6.  Cytotoxicity of rhein, the active metabolite of sennoside laxatives, is reduced by multidrug resistance-associated protein 1.

Authors:  B A P van Gorkom; H Timmer-Bosscha; S de Jong; D M van der Kolk; J H Kleibeuker; E G E de Vries
Journal:  Br J Cancer       Date:  2002-05-06       Impact factor: 7.640

7.  Melanosis coli: Harmless pigmentation? A case-control retrospective study of 657 cases.

Authors:  Zhong Hui Liu; Dominic Chi Chung Foo; Wai Lun Law; Fion Siu Yin Chan; Joe King Man Fan; Jun Sheng Peng
Journal:  PLoS One       Date:  2017-10-31       Impact factor: 3.240

8.  Gender, age, and concomitant diseases of melanosis coli in China: a multicenter study of 6,090 cases.

Authors:  Shufang Wang; Zikai Wang; Lihua Peng; Xiuli Zhang; Jianfeng Li; Yunsheng Yang; Bing Hu; Shoubin Ning; Bingyong Zhang; Junling Han; Ying Song; Gang Sun; Zhanguo Nie
Journal:  PeerJ       Date:  2018-03-08       Impact factor: 2.984

9.  Is senna laxative use associated to cathartic colon, genotoxicity, or carcinogenicity?

Authors:  M A Morales; D Hernández; S Bustamante; I Bachiller; A Rojas
Journal:  J Toxicol       Date:  2009-09-10

10.  Anti-proliferative effect of rhein, an anthraquinone isolated from Cassia species, on Caco-2 human adenocarcinoma cells.

Authors:  Gabriella Aviello; Ian Rowland; Christopher I Gill; Angela Maria Acquaviva; Francesco Capasso; Mark McCann; Raffaele Capasso; Angelo A Izzo; Francesca Borrelli
Journal:  J Cell Mol Med       Date:  2009-06-16       Impact factor: 5.310
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.