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Literature DB >> 11595634

Ricin.

Abstract

The plant toxin ricin consists of two disulfide-linked polypeptides with different functions. The A-chain enters the cytosol and inactivates the ribosomes enzymatically, whereas the B-chain has lectin properties and binds to carbohydrates at the cell surface. This binding is a requirement for translocation of the A-chain to the cytosol. The bound toxin is endocytosed and transported retrograde through the Golgi apparatus to the endoplasmic reticulum where it appears to be translocated to the cytosol by the sec61p complex.

Entities: Chemical Gene

Mesh：

Substances：
Ricin

Year: 2001 PMID： 11595634 DOI： 10.1016/s0041-0101(01)00158-1

Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033

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Cited

43 in total

1. Vibrio cholerae cytolysin is composed of an alpha-hemolysin-like core.

Authors: Rich Olson; Eric Gouaux
Journal: Protein Sci Date: 2003-02 Impact factor: 6.725

2. A method for the generation of combinatorial antibody libraries using pIX phage display.

Authors: Changshou Gao; Shenlan Mao; Gunnar Kaufmann; Peter Wirsching; Richard A Lerner; Kim D Janda
Journal: Proc Natl Acad Sci U S A Date: 2002-09-18 Impact factor: 11.205

3. Improved stability of a protein vaccine through elimination of a partially unfolded state.

Authors: Colleen A McHugh; Ralph F Tammariello; Charles B Millard; John H Carra
Journal: Protein Sci Date: 2004-08-31 Impact factor: 6.725

4. A tribute to Sjur: Sjur Olsnes, 1939-2014.

Authors: R John Collier
Journal: Pathog Dis Date: 2015-10-02 Impact factor: 3.166

5. Role of apoptotic signaling pathways in regulation of inflammatory responses to ricin in primary murine macrophages.

Authors: Veselina Korcheva; John Wong; Meghan Lindauer; David B Jacoby; Mihail S Iordanov; Bruce Magun
Journal: Mol Immunol Date: 2007-01-25 Impact factor: 4.407

6. Public health investigation after the discovery of ricin in a South Carolina postal facility.

Authors: Joshua G Schier; Manish M Patel; Martin G Belson; Amee Patel; Michael Schwartz; Nicole Fitzpatrick; Dan Drociuk; Scott Deitchman; Richard Meyer; Toby Litovitz; William A Watson; Carol H Rubin; Max Kiefer
Journal: Am J Public Health Date: 2007-04-05 Impact factor: 9.308

Ricin.

1. Vibrio cholerae cytolysin is composed of an alpha-hemolysin-like core.

2. A method for the generation of combinatorial antibody libraries using pIX phage display.

3. Improved stability of a protein vaccine through elimination of a partially unfolded state.

4. A tribute to Sjur: Sjur Olsnes, 1939-2014.

5. Role of apoptotic signaling pathways in regulation of inflammatory responses to ricin in primary murine macrophages.

6. Public health investigation after the discovery of ricin in a South Carolina postal facility.

7. Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway.

8. Protective effects of anti-ricin A-chain antibodies delivered intracellularly against ricin-induced cytotoxicity.

9. Expression of functional hexahistidine-tagged ricin B in tobacco.

Review 10. Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity.