| Literature DB >> 11595519 |
M Kottlors1, M Jaksch, U P Ketelsen, S Weiner, F X Glocker, C H Lücking.
Abstract
A 47-year-old man suffering from a bipolar disorder and intermittent myoglobinuria presented with acute rhabdomyolysis with renal failure after starting therapy with valproic acid. On morphological examination, skeletal muscle revealed increased lipid storage. Biochemically, decreased enzyme activity of carnitine palmitoyltransferase (CPT) type II with carnitine levels in the lower limit was found. Genetic analysis detected the common Ser113Leu substitution on one allele of the CPT2 gene. We conclude that valproic acid should be avoided in patients with CPT type II deficiency.Entities:
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Year: 2001 PMID： 11595519 DOI： 10.1016/s0960-8966(01)00228-0
Source DB: PubMed Journal: Neuromuscul Disord ISSN： 0960-8966 Impact factor: 4.296