| Literature DB >> 11595215 |
O E Zubareva1, I N Krasnova, I N Abdurasulova, R M Bluthe, R Dantzer, V M Klimenko.
Abstract
The ability of the brain serotonergic system to mediate the effects of interleukin-1beta (IL-1beta) was investigated. Intracerebroventricular administration of IL-1beta induced a significant pyrogenic reaction, depression in social behaviour, loss of body weight and reduced food intake in rats. Pre-treatment with p-chlorphenylalanine, an inhibitor of serotonin synthesis, blocked the IL-1beta-induced decrease in food intake and loss of body weight, but failed to alter the temperature increase and the decrease in communicative activity.Entities:
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Year: 2001 PMID： 11595215 DOI： 10.1016/s0006-8993(01)02910-9
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252