| Literature DB >> 11595214 |
K J Burman1, D J McKitrick, J B Minson, A West, L F Arnolda, I J Llewellyn-Smith.
Abstract
Substance P activation of neurokinin-1 (NK1) receptors on spinal sympathetic preganglionic neurons (SPN) influences blood pressure. We identified SPN likely to subserve the baroreceptor reflex and established if these neurons showed NK1 receptor-immunoreactivity. Nitroprusside (NP) infusion or inferior vena cava (IVC) constriction activated similar numbers of SPN. Of these, about 40% were NK1 receptor-immunoreactive after NP infusion, but only about 20% were NK1 receptor-immunoreactive after IVC constriction. The distribution of Fos/NK1 receptor SPN suggested that substance P may preferentially target sympathoadrenal SPN.Entities:
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Year: 2001 PMID： 11595214 DOI： 10.1016/s0006-8993(01)02907-9
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252