BACKGROUND: A survival difference has been seen in numerous studies between African-American (AA) and Caucasian (C) women with breast cancer. The purpose of this study was to elucidate the differences in patient characteristics and outcomes between AA and C women with breast cancer in our population. METHODS: We performed a retrospective analysis of 1345 women with newly diagnosed breast cancer who were entered into our tumor registry from October 1980 to December 1998. RESULTS: The association between race and stage at presentation was significant, as was the difference in the overall median survival between C and AA women. The data revealed no significant differences in survival between C and AA women presenting with Stage I or II disease. However, the differences between the median survival times for AA and C women presenting with Stage III and IV disease were both highly significant. A significantly lower percentage of AA women became "disease free" after initial therapy as compared with C women (P < 0.001). Interestingly, when data were stratified by stage, only in Stage III and IV were there significant differences between the races for becoming disease free. CONCLUSIONS: AA women tend to present at a later stage and have poorer survival from later-stage disease as compared with C women. The poorer survival appears to be related to the decreased ability to achieve disease-free status in AA women with advanced disease. The underlying causes of this difference in treatment outcome need further evaluation. Copyright 2001 Academic Press.
BACKGROUND: A survival difference has been seen in numerous studies between African-American (AA) and Caucasian (C) women with breast cancer. The purpose of this study was to elucidate the differences in patient characteristics and outcomes between AA and C women with breast cancer in our population. METHODS: We performed a retrospective analysis of 1345 women with newly diagnosed breast cancer who were entered into our tumor registry from October 1980 to December 1998. RESULTS: The association between race and stage at presentation was significant, as was the difference in the overall median survival between C and AA women. The data revealed no significant differences in survival between C and AA women presenting with Stage I or II disease. However, the differences between the median survival times for AA and C women presenting with Stage III and IV disease were both highly significant. A significantly lower percentage of AA women became "disease free" after initial therapy as compared with C women (P < 0.001). Interestingly, when data were stratified by stage, only in Stage III and IV were there significant differences between the races for becoming disease free. CONCLUSIONS: AA women tend to present at a later stage and have poorer survival from later-stage disease as compared with C women. The poorer survival appears to be related to the decreased ability to achieve disease-free status in AA women with advanced disease. The underlying causes of this difference in treatment outcome need further evaluation. Copyright 2001 Academic Press.
Authors: Sidney W Fu; Arnold Schwartz; Holly Stevenson; Joseph J Pinzone; Gregory J Davenport; Jan M Orenstein; Peter Gutierrez; Samuel J Simmens; Jessy Abraham; Indira Poola; Dietrich A Stephan; Patricia E Berg Journal: Breast Cancer Res Date: 2003-04-22 Impact factor: 6.466
Authors: Sidney W Fu; Saurabh P Kirolikar; Erika Ginsburg; Xiaohui Tan; Arnold Schwartz; Samuel J Simmens; Yan-Gao Man; Joseph J Pinzone; Christine Teal; Sanket Awate; Barbara K Vonderhaar; Patricia E Berg Journal: Oncotarget Date: 2016-08-16
Authors: Behjatolah Monzavi-Karbassi; Eric R Siegel; Srikanth Medarametla; Issam Makhoul; Thomas Kieber-Emmons Journal: Oncol Lett Date: 2016-06-29 Impact factor: 2.967