Literature DB >> 11591696

Killing effect and antitoxic activity of the Leptospira interrogans toxin-antitoxin system in Escherichia coli.

M Picardeau1, S Ren, I Saint Girons.   

Abstract

We report the first evidence of a chromosome-encoded toxin-antitoxin locus in spirochetes. This locus has been found in the pathogenic spirochete Leptospira interrogans and exhibits homologies with the pem/chp loci. The L. interrogans chp locus consists of two genes: chpK (for "killer protein") and its upstream partner chpI (for "inhibitory protein"). Expression of ChpK in Escherichia coli results in the inhibition of bacterial growth. The coexpression of ChpI neutralizes ChpK toxicity. By Southern blot analysis, chp homologs were found in all representative pathogenic strains of L. interrogans.

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Year:  2001        PMID： 11591696      PMCID： PMC100147          DOI： 10.1128/JB.183.21.6494-6497.2001

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  10 in total

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Authors:  P Kristoffersen; G B Jensen; K Gerdes; J Piskur
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Review 3.  Addiction modules and programmed cell death and antideath in bacterial cultures.

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4.  Kid, a small protein of the parD stability system of plasmid R1, is an inhibitor of DNA replication acting at the initiation of DNA synthesis.

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Journal:  J Mol Biol       Date:  1995-04-07       Impact factor: 5.469

5.  First evidence for gene replacement in Leptospira spp. Inactivation of L. biflexa flaB results in non-motile mutants deficient in endoflagella.

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6.  Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.

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7.  Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.

Authors:  R D Fleischmann; M D Adams; O White; R A Clayton; E F Kirkness; A R Kerlavage; C J Bult; J F Tomb; B A Dougherty; J M Merrick
Journal:  Science       Date:  1995-07-28       Impact factor: 47.728

8.  chpA and chpB, Escherichia coli chromosomal homologs of the pem locus responsible for stable maintenance of plasmid R100.

Authors:  Y Masuda; K Miyakawa; Y Nishimura; E Ohtsubo
Journal:  J Bacteriol       Date:  1993-11       Impact factor: 3.490

9.  Autoregulation by cooperative binding of the PemI and PemK proteins to the promoter region of the pem operon.

Authors:  S Tsuchimoto; E Ohtsubo
Journal:  Mol Gen Genet       Date:  1993-02

10.  Complete genome sequence of Treponema pallidum, the syphilis spirochete.

Authors:  C M Fraser; S J Norris; G M Weinstock; O White; G G Sutton; R Dodson; M Gwinn; E K Hickey; R Clayton; K A Ketchum; E Sodergren; J M Hardham; M P McLeod; S Salzberg; J Peterson; H Khalak; D Richardson; J K Howell; M Chidambaram; T Utterback; L McDonald; P Artiach; C Bowman; M D Cotton; C Fujii; S Garland; B Hatch; K Horst; K Roberts; M Sandusky; J Weidman; H O Smith; J C Venter
Journal:  Science       Date:  1998-07-17       Impact factor: 47.728
  10 in total
  6 in total

1.  A genomic island of the pathogen Leptospira interrogans serovar Lai can excise from its chromosome.

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Journal:  Infect Immun       Date:  2006-11-21       Impact factor: 3.441

2.  Complete nucleotide sequence of the LE1 prophage from the spirochete Leptospira biflexa and characterization of its replication and partition functions.

Authors:  Pascale Bourhy; Lionel Frangeul; Elisabeth Couvé; Philippe Glaser; Isabelle Saint Girons; Mathieu Picardeau
Journal:  J Bacteriol       Date:  2005-06       Impact factor: 3.490

3.  Whole genome analysis of Leptospira licerasiae provides insight into leptospiral evolution and pathogenicity.

Authors:  Jessica N Ricaldi; Derrick E Fouts; Jeremy D Selengut; Derek M Harkins; Kailash P Patra; Angelo Moreno; Jason S Lehmann; Janaki Purushe; Ravi Sanka; Michael Torres; Nicholas J Webster; Joseph M Vinetz; Michael A Matthias
Journal:  PLoS Negl Trop Dis       Date:  2012-10-25

4.  VapC from the leptospiral VapBC toxin-antitoxin module displays ribonuclease activity on the initiator tRNA.

Authors:  Alexandre P Y Lopes; Luana M Lopes; Tatiana R Fraga; Rosa M Chura-Chambi; André L Sanson; Elisabeth Cheng; Erika Nakajima; Ligia Morganti; Elizabeth A L Martins
Journal:  PLoS One       Date:  2014-07-21       Impact factor: 3.240

5.  Isolation and characterization of two novel plasmids from pathogenic Leptospira interrogans serogroup Canicola Serovar Canicola strain Gui44.

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Review 6.  Leptospiral pathogenomics.

Authors:  Jason S Lehmann; Michael A Matthias; Joseph M Vinetz; Derrick E Fouts
Journal:  Pathogens       Date:  2014-04-10
  6 in total

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