| Literature DB >> 11591519 |
L M Tillekeratne1, A Sherette, P Grossman, L Hupe, D Hupe, R A Hudson.
Abstract
Systematic simplification of the molecular structures of epicatechin gallate and epigallocatechin gallate to determine the minimum structural characteristics necessary for HIV-1 reverse transcriptase inhibition in vitro resulted in several compounds that strongly inhibited the native as well as the A17 double mutant (K103N Y181C) enzyme, which is normally insensitive to most known nonnucleoside inhibitors.Entities:
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Year: 2001 PMID： 11591519 DOI： 10.1016/s0960-894x(01)00577-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823