| Literature DB >> 11591510 |
D P Becker1, G DeCrescenzo, J Freskos, D P Getman, S L Hockerman, M Li, P Mehta, G E Munie, C Swearingen.
Abstract
A series of alpha-alkyl-alpha-amino-beta-sulphone hydroxamates was prepared and evaluated for potency versus MMP-2 and MMP-13, and for selectivity versus MMP-1. Low nanomolar potency was obtained with selectivity versus MMP-1 ranging from >10 to >1000. Selected compounds were orally bioavailable.Entities:
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Year: 2001 PMID： 11591510 DOI： 10.1016/s0960-894x(01)00557-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823