| Literature DB >> 11591509 |
D P Becker1, T E Barta, L Bedell, G DeCrescenzo, J Freskos, D P Getman, S L Hockerman, M Li, P Mehta, B Mischke, G E Munie, C Swearingen, C I Villamil.
Abstract
A series of alpha-amino-beta-sulphone hydroxamates was prepared and evaluated for potency versus MMP-13 and selectivity versus MMP-1. Various substituents were employed on the alpha-amino group (P(1) position), as well as different groups attached to the sulphone group extending into P(1)'. Low nanomolar potency was obtained for MMP-13 with selectivity versus MMP-1 of >1000x for a number of analogues.Entities:
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Year: 2001 PMID： 11591509 DOI： 10.1016/s0960-894x(01)00556-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823